Matches in SemOpenAlex for { <https://semopenalex.org/work/W3030835475> ?p ?o ?g. }
- W3030835475 endingPage "309" @default.
- W3030835475 startingPage "289" @default.
- W3030835475 abstract "Ivermectin, as an old anti-parasite drug, can suppress almost completely the growth of various human cancers, including ovarian cancer (OC). However, its anticancer mechanism remained to be further studied at the molecular levels. Ivermectin-related molecule-panel changes will serve a useful tool for its personalized drug therapy and prognostic assessment in OCs.To explore the functional significance of ivermectin-mediated lncRNA-EIF4A3-mRNA axes in OCs and ivermectin-related molecule-panel for its personalized drug therapy monitoring.Based on our previous study, a total of 16 lncRNA expression patterns were analyzed using qRT-PCR before and after ivermectin-treated different OC cell lines (TOV-21G and A2780). Stable isotope labeling with amino acids in cell culture (SILAC)-based quantitative proteomics was used to analyze the protein expressions of EIF4A3 and EIF4A3-binding mRNAs in ovarian cancer cells treated with and without ivermectin. A total of 411 OC patients from the Cancer Genome Atlas (TCGA) database with the selected lncRNA expressions and the corresponding clinical data were included. Lasso regression was constructed to examine the relationship between lncRNA signature and OC survival risk. The overall survival analysis between high-risk and low-risk groups used the Kaplan-Meier method. Heatmap showed the correlation between risk groups and clinical characteristics. The univariate and multivariate models were established with Cox regression.SILAC-based quantitative proteomics found the protein expression levels of EIF4A3 and 116 EIF4A3-binding mRNAs were inhibited by ivermectin in OC cells. Among the analyzed 16 lncRNAs (HCG15, KIF9-AS1, PDCD4-AS1, ZNF674-AS1, ZNRF3-AS1, SOS1-IT1, LINC00565, SNHG3, PLCH1-AS1, WWTR1-AS1, LINC00517, AL109767.1, STARD13-IT1, LBX2-AS1, LEMD1-AS1, and HOXC-AS3), only 7 lncRNAs (HCG15, KIF9-AS1, PDCD4-AS1, ZNF674-AS1, ZNRF3-AS1, SOS1-IT1, and LINC00565) were obtained for further lasso regression when combined with the results of drug testing and overall survival analysis. Lasso regression identified the prognostic model of ivermectin-related three-lncRNA signature (ZNRF3-AS1, SOS1-IT1, and LINC00565). The high-risk and low-risk groups based on the prognostic model were significantly related to overall survival and clinicopathologic characteristics (survival status, lymphatic invasion, cancer status, and clinical stage) in OC patients and remained independent risk factors according to multivariate COX analysis (p < 0.05).Those findings provided the potential targeted lncRNA-EIF4A3-mRNA pathways of ivermectin in OC, and constructed the effective prognostic model, which benefits discovery of novel mechanism of ivermectin to suppress ovarian cancer cells, and the ivermectin-related molecule-panel changes benefit for its personalized drug therapy and prognostic assessment towards its predictive, preventive, and personalized medicine (PPPM) in OCs." @default.
- W3030835475 created "2020-06-05" @default.
- W3030835475 creator A5014615941 @default.
- W3030835475 creator A5031315906 @default.
- W3030835475 date "2020-05-28" @default.
- W3030835475 modified "2023-10-14" @default.
- W3030835475 title "Anti-parasite drug ivermectin can suppress ovarian cancer by regulating lncRNA-EIF4A3-mRNA axes" @default.
- W3030835475 cites W1941580068 @default.
- W3030835475 cites W1970073870 @default.
- W3030835475 cites W1983849953 @default.
- W3030835475 cites W2002129385 @default.
- W3030835475 cites W2036402097 @default.
- W3030835475 cites W2045404017 @default.
- W3030835475 cites W2085391180 @default.
- W3030835475 cites W2112321374 @default.
- W3030835475 cites W2116624561 @default.
- W3030835475 cites W2161675674 @default.
- W3030835475 cites W2165115006 @default.
- W3030835475 cites W2300010382 @default.
- W3030835475 cites W2334083046 @default.
- W3030835475 cites W2426965800 @default.
- W3030835475 cites W2462101166 @default.
- W3030835475 cites W2484974310 @default.
- W3030835475 cites W2532686299 @default.
- W3030835475 cites W2553465232 @default.
- W3030835475 cites W2587955855 @default.
- W3030835475 cites W2590878552 @default.
- W3030835475 cites W2592500806 @default.
- W3030835475 cites W2593557252 @default.
- W3030835475 cites W2605442325 @default.
- W3030835475 cites W2610428013 @default.
- W3030835475 cites W2617481668 @default.
- W3030835475 cites W2745468516 @default.
- W3030835475 cites W2748186584 @default.
- W3030835475 cites W2772751836 @default.
- W3030835475 cites W2783142161 @default.
- W3030835475 cites W2789589546 @default.
- W3030835475 cites W2792232717 @default.
- W3030835475 cites W2792425071 @default.
- W3030835475 cites W2800412001 @default.
- W3030835475 cites W2803233756 @default.
- W3030835475 cites W2808564631 @default.
- W3030835475 cites W2855168245 @default.
- W3030835475 cites W2891907584 @default.
- W3030835475 cites W2895271314 @default.
- W3030835475 cites W2896198585 @default.
- W3030835475 cites W2896442376 @default.
- W3030835475 cites W2896894658 @default.
- W3030835475 cites W2902013383 @default.
- W3030835475 cites W2902840833 @default.
- W3030835475 cites W2903319356 @default.
- W3030835475 cites W2905215435 @default.
- W3030835475 cites W2918672521 @default.
- W3030835475 cites W2941280883 @default.
- W3030835475 cites W2944835160 @default.
- W3030835475 cites W2954433278 @default.
- W3030835475 cites W2961401903 @default.
- W3030835475 cites W2963504068 @default.
- W3030835475 cites W2964370893 @default.
- W3030835475 cites W2966695300 @default.
- W3030835475 cites W2981366800 @default.
- W3030835475 cites W2981763939 @default.
- W3030835475 cites W2987245182 @default.
- W3030835475 cites W2987735094 @default.
- W3030835475 cites W2990730477 @default.
- W3030835475 cites W2998019334 @default.
- W3030835475 cites W3651239 @default.
- W3030835475 doi "https://doi.org/10.1007/s13167-020-00209-y" @default.
- W3030835475 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7272521" @default.
- W3030835475 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32549918" @default.
- W3030835475 hasPublicationYear "2020" @default.
- W3030835475 type Work @default.
- W3030835475 sameAs 3030835475 @default.
- W3030835475 citedByCount "33" @default.
- W3030835475 countsByYear W30308354752020 @default.
- W3030835475 countsByYear W30308354752021 @default.
- W3030835475 countsByYear W30308354752022 @default.
- W3030835475 countsByYear W30308354752023 @default.
- W3030835475 crossrefType "journal-article" @default.
- W3030835475 hasAuthorship W3030835475A5014615941 @default.
- W3030835475 hasAuthorship W3030835475A5031315906 @default.
- W3030835475 hasBestOaLocation W30308354751 @default.
- W3030835475 hasConcept C104317684 @default.
- W3030835475 hasConcept C121608353 @default.
- W3030835475 hasConcept C126322002 @default.
- W3030835475 hasConcept C143998085 @default.
- W3030835475 hasConcept C2777499811 @default.
- W3030835475 hasConcept C2780427987 @default.
- W3030835475 hasConcept C34905852 @default.
- W3030835475 hasConcept C46111723 @default.
- W3030835475 hasConcept C502942594 @default.
- W3030835475 hasConcept C54355233 @default.
- W3030835475 hasConcept C60644358 @default.
- W3030835475 hasConcept C71924100 @default.
- W3030835475 hasConcept C80311884 @default.
- W3030835475 hasConcept C86803240 @default.
- W3030835475 hasConcept C90856448 @default.
- W3030835475 hasConcept C98274493 @default.