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- W3030835680 abstract "ObjectiveTo effectively combine the results of resting state regional homogeneity(ReHo) fMRI studies in depression.MethodsLiteratures between 2003-2016 on fMRI of depression in PubMed, Web of Knowledge, EBSCO host medline, CNKI, CQVIP and Wanfang Med Online were taken as research objects.Screening the relevant data according to the included and excluded standard, then, software of AES-SDM was employed to do Meta analysis, in addition, the age, gender, duration of disease, the year of education and treatment were also analyzed.Results23 articles met the standard, including 1 036 cases, of which 507 for the depression group, 529 for the control group. Meta analysis showed the significant ReHo abnormalities of Default Mode Network(DMN) which centers on left precuneus, left superior frontal gyrus and right cingulate gyrus, in addition, left lenticular nucleus, left postcentral gyrus, left cerebellum and left fusiform gyrus had significant ReHo differences. In the regression analysis, gender, age, duration of disease, years of education, disease severity were all affected factors. The difference of cingulate gyrus was the most stable, and the duration of the disease significantly affected cingulate gyrus(SDM=2.777).ConclusionThe abnormalities of DMN which centers on left precuneus, left, medial superior frontal gyrus and right cingulate gyrus are the most consistent in depression, the DMN is closely related to depression.Key words: FMRI; Meta-analysis; AES-SDM; Depression" @default.
- W3030835680 created "2020-06-05" @default.
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- W3030835680 date "2017-04-20" @default.
- W3030835680 modified "2023-10-17" @default.
- W3030835680 title "Regional homogeneity in depression: a meta-analysis of resting-state functional-MRI studies" @default.
- W3030835680 doi "https://doi.org/10.3760/cma.j.issn.1674-6554.2017.04.019" @default.
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