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- W3030844146 abstract "Objective To study the effects of acid-sensor ion channels activation or inhibition on the epileptic discharge in EEG of epilepsy rat model induced by Lithium-pilocarpine.Methods Seizures were intraperitoneally induced in rats with lithium-pilocarpine.The rats were divided into four groups:the placebo group,the ASICs inhibitor group,the positive control group and the ASICs activator group by administrating intraperitoneally PBS,amiloride,Levetiracetam or acidic liquids,respectively.The number of discharge,and amplitude and interval of discharge were selected as the indicators for comparison.Results Sixty-ninety min after the injection,the number of discharge (0.69 ± 0.08 ) and the amplitude (0.70 ± 0.16) were reduced in the ASICs inhibitor group,while the interval of discharge was increased (1.46 ± 0.18) (P ＜ 0.05) as compared with the placebo group.In the ASICs activator group,the number of discharge ( 1.05 ± 0.07) was increased 30 min after injection.Conclusion Amiloride can inhibit epilepsy induced by lithium-pilocarpine,while acid liquids exert the opposite effects,which may be concerned with the inhibition or activation of ASICs channel.Key words: Pilocarpine; Amiloride; Acid-sensing ion channel; Epilepsy" @default.
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- W3030844146 date "2012-08-08" @default.
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- W3030844146 title "Acid-sensor ion channels activation/inhibition on rats with lithium pilocarpine-induced epilepsy" @default.
- W3030844146 doi "https://doi.org/10.3760/cma.j.issn.1001-9030.2012.08.051" @default.
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