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• W30308463 startingPage "357" @default.
• W30308463 abstract "Dementia is a relatively well-defined condition characterized by a progressive decline of cognitive and performances, as a consequence of degenerative and/or vascular brain changes. Although the definition of stress remains still problematic, it is now well known that a chronic exposure to stressors is usually able to disrupt the physiological balance both at the cellular or the organism level, and to play a role in the onset and progression of some pathological conditions. Within this context, at systemic level stress includes all the neurohormonal and metabolic responses of the organism to external stressors; at cellular level, stress, mostly oxidative stress, may instead be a correlate of the aging process itself. The link between stress and cognitive impairment is probably to be found in the hippocampal changes, a crucial as well as vulnerable brain area involved in mood, cognitive and behavioural control, and in the mean time, a site with a very high density of glucocorticoid (GR) and mineralocorticoid (MR) receptors. Therefore, the hippocampal neuronal impairment is responsible for a continuous stress-induced activation of the hypothalamic–pituitary–adrenal (HPA) axis and an increased hypothalamic expression of corticotropin releasing factor (CRF) and vasopressin. Furthermore, the age-related changes of the adrenocortical secretory pattern could play a role in the pathophysiology of brain aging, fostering the brain exposure to a neurotoxic hormonal pattern. In this chapter, we examine particularly the evidence for a link between dementia and HPA activity on the basis of the data in the literature as well as of our personal findings." @default.
• W30308463 created "2016-06-24" @default.
• W30308463 creator A5035496553 @default.
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• W30308463 creator A5062132921 @default.
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• W30308463 creator A5082306007 @default.
• W30308463 date "2005-01-01" @default.
• W30308463 modified "2023-09-25" @default.
• W30308463 title "Stress and dementia" @default.
• W30308463 cites W1500145074 @default.
• W30308463 cites W1546705008 @default.
• W30308463 cites W1547358456 @default.
• W30308463 cites W1548230964 @default.
• W30308463 cites W1642124290 @default.
• W30308463 cites W1668301680 @default.
• W30308463 cites W1731253253 @default.
• W30308463 cites W1804267428 @default.
• W30308463 cites W1896970469 @default.
• W30308463 cites W1907556419 @default.
• W30308463 cites W1963568158 @default.
• W30308463 cites W1965318035 @default.
• W30308463 cites W1965797097 @default.
• W30308463 cites W1968828040 @default.
• W30308463 cites W1968938847 @default.
• W30308463 cites W1975502679 @default.
• W30308463 cites W1977143695 @default.
• W30308463 cites W1981480708 @default.
• W30308463 cites W1987510933 @default.
• W30308463 cites W1988015375 @default.
• W30308463 cites W1988157043 @default.
• W30308463 cites W1988694091 @default.
• W30308463 cites W1989135441 @default.
• W30308463 cites W1995824690 @default.
• W30308463 cites W1997800886 @default.
• W30308463 cites W2002658702 @default.
• W30308463 cites W2003524311 @default.
• W30308463 cites W2005799786 @default.
• W30308463 cites W2008050722 @default.
• W30308463 cites W2008111036 @default.
• W30308463 cites W2008301967 @default.
• W30308463 cites W2012618926 @default.
• W30308463 cites W2016998675 @default.
• W30308463 cites W2017164258 @default.
• W30308463 cites W2018460687 @default.
• W30308463 cites W2025468569 @default.
• W30308463 cites W2026846044 @default.
• W30308463 cites W2028447550 @default.
• W30308463 cites W2028989537 @default.
• W30308463 cites W2029404396 @default.
• W30308463 cites W2033017137 @default.
• W30308463 cites W2035489261 @default.
• W30308463 cites W2036931212 @default.
• W30308463 cites W2037515570 @default.
• W30308463 cites W2040761658 @default.
• W30308463 cites W2043827506 @default.
• W30308463 cites W2043982245 @default.
• W30308463 cites W2044451089 @default.
• W30308463 cites W2049358643 @default.
• W30308463 cites W2051437126 @default.
• W30308463 cites W2051715358 @default.
• W30308463 cites W2052742260 @default.
• W30308463 cites W2056003714 @default.
• W30308463 cites W2058350561 @default.
• W30308463 cites W2059012500 @default.
• W30308463 cites W2061405220 @default.
• W30308463 cites W2062452627 @default.
• W30308463 cites W2064215179 @default.
• W30308463 cites W2064476272 @default.
• W30308463 cites W2064651531 @default.
• W30308463 cites W2067820958 @default.
• W30308463 cites W2068982826 @default.
• W30308463 cites W2070746053 @default.
• W30308463 cites W2071673220 @default.
• W30308463 cites W2072612731 @default.
• W30308463 cites W2074308026 @default.
• W30308463 cites W2074802748 @default.
• W30308463 cites W2074818973 @default.
• W30308463 cites W2075310845 @default.
• W30308463 cites W2075867944 @default.
• W30308463 cites W2076160743 @default.
• W30308463 cites W2077792351 @default.
• W30308463 cites W2079014559 @default.
• W30308463 cites W2083500052 @default.
• W30308463 cites W2085047375 @default.
• W30308463 cites W2094493191 @default.
• W30308463 cites W2107195919 @default.
• W30308463 cites W2116784956 @default.
• W30308463 cites W2119126576 @default.
• W30308463 cites W2123669610 @default.
• W30308463 cites W2124124560 @default.
• W30308463 cites W2128136330 @default.
• W30308463 cites W2130753450 @default.
• W30308463 cites W2131633241 @default.
• W30308463 cites W2131751497 @default.
• W30308463 cites W2136669639 @default.
• W30308463 cites W2137620339 @default.
• W30308463 cites W2139803108 @default.

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