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- W3030848632 abstract "Abstract Even when IgG, IgG-subclasses, IgA and IgM have normal levels in serum, a person can still suffer from a clinically significant form of antibody deficiency: specific antibody deficiency (SAD). Patients with SAD generally present with recurrent, chronic and/or severe rhinosinusitis and bronchopulmonary infections. To diagnose these patients, the specific response to polysaccharide antigen is generally tested using unconjugated 23-valent pneumococcal vaccine (PPV23). Because low responsiveness to polysaccharide antigens can be physiological in infants, children should not be tested with PPV23 before the age of 2, preferably even 3–4, years. Appropriate treatment depends on the clinical condition of the patient. Antibiotic prophylaxis, year-round or only in the winter months, is an option. In cases with severe clinical manifestations, immunoglobulin substitution through the subcutaneous or intravenous route is warranted." @default.
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- W3030848632 date "2020-01-01" @default.
- W3030848632 modified "2023-10-14" @default.
- W3030848632 title "Specific antibody deficiency" @default.
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- W3030848632 doi "https://doi.org/10.1016/b978-0-12-816768-7.00021-1" @default.
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