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- W3030853907 abstract "Treatment effectiveness of multiple myeloma (MM), a hematological malignancy which is difficult to detect and treat, is mainly treated with chemotherapy and hindered by the existence of drug resistance. MicroRNA (miRNA) is new hotspot raised in the recent studies in the field of biology and pathogenesis of cancer. As a small, non-coding RNA molecule, miRNA participates in the post-transcribed translation in many human genes, including oncogenes and tumor suppressor genes, which play an important role in negative regulation. Therefore, miRNA is a hotpot in pathogenesis of cancer, the research of miRNA opens up a new window for further understanding of tumor drug resistance. Involvement of miRNA in the pathogenesis and disease progression of MM has been well proved, but its involvement in the studies of MM resistance is still in its initial stage. This article reviews the latest findings on the role of miRNA in MM resistance, and discusses how to apply miRNA in clinical treatment and overcome MM resistance.Key words: Multiple myeloma; MicroRNAs; Drug resistance; Hematologic malignancies; Tumor stem cell" @default.
- W3030853907 created "2020-06-05" @default.
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- W3030853907 date "2018-07-20" @default.
- W3030853907 modified "2023-09-23" @default.
- W3030853907 title "Research progress of microRNA and drug resistance of multiple myeloma" @default.
- W3030853907 doi "https://doi.org/10.3760/cma.j.issn.1673-419x.2018.04.013" @default.
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