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- W3030857518 abstract "Objective To study the pharmacokinetics and tissue distribution of intraperitoneal aerosol 5-fluorouracil （5-Fu） in rats. Methods Thirty SD rats were randomized into 1, 3, 6, 12, 18, 24 h time point groups; the 5-Fu （0. 1 ml/g） in aerosol was perfused into the abdominal cavities of rats with self-developed instrument. The blood of the portal vein and inferior vena cava, and samples of the colon, stomach, liver, kidney and lung were collected on the corresponding time points ; the concentrations of 5- Fu in the samples were determinated by using high performance liquid chromatography （HPLC）. Results The peak drug concentrations of the peritoneal fluid, blood of the portal vein and inferior vena cava, tissues of the colon, stomach, liver, kidney and lung all appeared in the 1 h group, and drug concentration was decreased along with time ; the peak drug concentration of peritoneal fluid in 1 h group was 259. 7730 mg/L. The peak drug concentration of portal vein blood in the 1 h group was 7. 4933 mg/L, about 1.3 times higher than that of inferior vena cava blood （5. 5930 mg/L）. Among the visceral organs, the peak drug concentration of renal tissue （2. 4030 mg/L） in 1 h group was highest, followed by that of the lung, stomach, colon, liver in turn. Conclusion Intraperitoneal aerosol chemotherapy with 5-Fu has pharmacokinetic advantages, which can kill free cancer cells and micro-cancers probably.Key words: Intraperitoneal aerosol chemotherapy; Pharmacokinetics; Laparoscopy; 5-Fu ; High-performance liquid chromatography" @default.
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- W3030857518 date "2011-01-08" @default.
- W3030857518 modified "2023-09-25" @default.
- W3030857518 title "Pharmacokinetics and tissue distribution of intraperitoneal aerosol 5-fluorouracil in rats" @default.
- W3030857518 doi "https://doi.org/10.3760/cma.j.issn.1001-9030.2011.01.015" @default.
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