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- W3030860275 abstract "目的:观察拓扑替康的血液毒性反应,评价拓扑替康在临床应用的安全性.方法:113例初次接受3个周期化疗的非小细胞肺癌患者分为三组,TP组53例(拓扑替康0.75mg/m2,顺铂20mg/m2,第1～5天);NP组30例(去甲长春花碱25mg/m2,第1,8天,顺铂20mg/m2,第1～5天);HP组30例(羟基喜树碱6mg/m2,顺铂20mg/m2,第1～5天);21天为1个周期.第3周期末评价血液毒性.结果:化疗有效率TP组39.62%,NP组33.33%,HP组30.00%,组间比较无显著性差异(P＞0.05);三组血液毒性反应中,TP组白细胞Ⅲ级下降18例,Ⅳ级15例,Ⅲ～Ⅳ级下降占62.26%,白细胞Ⅲ～Ⅳ级下降与NP和HP组比较均有显著性差异(P＜0.05);TP组血小板Ⅲ级下降15例,Ⅳ级下降13例,Ⅲ～Ⅳ级下降占52.83%.血小板Ⅲ～Ⅳ级下降反应与NP组和HP组比较也有显著性差异(P＜0.05).结论:拓扑替康具有较重的血液毒性反应,尤其是Ⅲ～Ⅳ级反应,以白细胞和血小板下降为主.临床应用期间应注意血象监测,适时采取措施,即使发生Ⅲ～Ⅳ级骨髓抑制反应,对患者也是安全的." @default.
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- W3030860275 date "2003-06-28" @default.
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- W3030860275 title "Investigation of blood toxicity in association with topotecan" @default.
- W3030860275 doi "https://doi.org/10.3969/j.issn.1008-5734.2003.03.009" @default.
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