FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3030876242> ?p ?o ?g. }

• W3030876242 endingPage "669" @default.
• W3030876242 startingPage "665" @default.
• W3030876242 abstract "ObjectiveTo investigate the clinical characteristics, treatment strategies and curative effect of recurrence and metastasis of primary gastrointestinal stromal tumor (GIST) after complete resection along with adjuvant therapy with imatinib, and to analyze the risk factors of recurrence and metastasis after adjuvant therapy.MethodsThe demographic data, clinicopathological characteristics and follow-up data of 80 primary GIST patients who received adjuvant therapy with imatinib for at least 1-year duration and had already stopped taking imatinib from January 2005 to December 2017 in Union Hospital, Tongji Medical College, Huazhong University of Science and Technology were analyzed retrospectively. The survival analysis was performed using Kaplan-Meier approach. Univariate analysis was conducted using log-rank test. Multivariate analysis was produced by Cox regression model.ResultsOf the enrolled 80 patients, recurrence and metastasis were detected in 17 cases after completion of postoperative adjuvant therapy with imatinib, with a median recurrence time of 12 months. All the 17 patients showed no specific clinical manifestations. Liver metastasis, peritoneum metastasis and local recurrence were found in 9, 5 and 3 cases, respectively. In the 17 patients with recurrence and metastasis, 9 patients received imatinib monotherapy. Among the 9 patients, 6 achieved partial responses, while 3 demonstrated stable disease, and secondary drug resistance was found in 7 patients during the follow-up period, with a median progression-free survival of 35 months (95%CI: 15-55 months) and median overall survival of 49 months (95%CI: 30-68 months). A total of 7 patients with recurrence and metastasis were treated with imatinib after operation and achieved satisfying tumor control, and secondary drug resistance was found in 4 patients during the follow-up period, with a median progression-free survival of 31 months (95%CI: 6-56 months) and fell short of median overall survival. The remaining 1 patient gave up treatment. Univariate analysis showed that tumor location (χ2=4.120, P=0.042), preoperative neutrophil-to-lymphocyte ratio (NLR) (χ2=7.513, P=0.006) and preoperative platelet-to-lymphocyte ratio (PLR) (χ2=6.575, P=0.010) were associated with recurrence and metastasis of GIST patients after completion of adjuvant therapy. Multivariate analysis revealed that tumor location (HR=3.787, 95%CI: 1.126-12.732, χ2=4.631, P=0.031) was an independent prognostic factor for those patients.ConclusionGIST patients who are identified recurrence and metastasis after completion of adjuvant imatinib treatment show no specific clinical manifestations after stopping andjuvant therapy with imatinib. Compared with gastric GIST, non-gastric origin GIST has a higher risk of recurrence. Imatinib monotherapy and surgery combined with imatinib therapy are both effective in treating this subgroup of patients.Key words: Gastrointestinal stromal tumor; Neoplasm recurrence, local; Neoplasm metastasis; Imatinib" @default.
• W3030876242 created "2020-06-05" @default.
• W3030876242 creator A5029360035 @default.
• W3030876242 creator A5043543046 @default.
• W3030876242 creator A5044330762 @default.
• W3030876242 creator A5062115626 @default.
• W3030876242 creator A5068398145 @default.
• W3030876242 creator A5074185870 @default.
• W3030876242 creator A5079375938 @default.
• W3030876242 creator A5079796208 @default.
• W3030876242 creator A5085142676 @default.
• W3030876242 date "2018-11-08" @default.
• W3030876242 modified "2023-09-23" @default.
• W3030876242 title "Analysis of diagnosis and treatment of gastrointestinal stromal tumor recurrence and metastasis after postoperative adjuvant imatinib treatment" @default.
• W3030876242 doi "https://doi.org/10.3760/cma.j.issn.1673-422x.2018.11.006" @default.
• W3030876242 hasPublicationYear "2018" @default.
• W3030876242 type Work @default.
• W3030876242 sameAs 3030876242 @default.
• W3030876242 citedByCount "0" @default.
• W3030876242 crossrefType "journal-article" @default.
• W3030876242 hasAuthorship W3030876242A5029360035 @default.
• W3030876242 hasAuthorship W3030876242A5043543046 @default.
• W3030876242 hasAuthorship W3030876242A5044330762 @default.
• W3030876242 hasAuthorship W3030876242A5062115626 @default.
• W3030876242 hasAuthorship W3030876242A5068398145 @default.
• W3030876242 hasAuthorship W3030876242A5074185870 @default.
• W3030876242 hasAuthorship W3030876242A5079375938 @default.
• W3030876242 hasAuthorship W3030876242A5079796208 @default.
• W3030876242 hasAuthorship W3030876242A5085142676 @default.
• W3030876242 hasConcept C10515644 @default.
• W3030876242 hasConcept C121608353 @default.
• W3030876242 hasConcept C126322002 @default.
• W3030876242 hasConcept C141071460 @default.
• W3030876242 hasConcept C143998085 @default.
• W3030876242 hasConcept C144301174 @default.
• W3030876242 hasConcept C16930146 @default.
• W3030876242 hasConcept C2775922572 @default.
• W3030876242 hasConcept C2777007597 @default.
• W3030876242 hasConcept C2777583451 @default.
• W3030876242 hasConcept C2777863537 @default.
• W3030876242 hasConcept C2777982462 @default.
• W3030876242 hasConcept C2778729363 @default.
• W3030876242 hasConcept C2779013556 @default.
• W3030876242 hasConcept C38180746 @default.
• W3030876242 hasConcept C50382708 @default.
• W3030876242 hasConcept C71924100 @default.
• W3030876242 hasConcept C90924648 @default.
• W3030876242 hasConceptScore W3030876242C10515644 @default.
• W3030876242 hasConceptScore W3030876242C121608353 @default.
• W3030876242 hasConceptScore W3030876242C126322002 @default.
• W3030876242 hasConceptScore W3030876242C141071460 @default.
• W3030876242 hasConceptScore W3030876242C143998085 @default.
• W3030876242 hasConceptScore W3030876242C144301174 @default.
• W3030876242 hasConceptScore W3030876242C16930146 @default.
• W3030876242 hasConceptScore W3030876242C2775922572 @default.
• W3030876242 hasConceptScore W3030876242C2777007597 @default.
• W3030876242 hasConceptScore W3030876242C2777583451 @default.
• W3030876242 hasConceptScore W3030876242C2777863537 @default.
• W3030876242 hasConceptScore W3030876242C2777982462 @default.
• W3030876242 hasConceptScore W3030876242C2778729363 @default.
• W3030876242 hasConceptScore W3030876242C2779013556 @default.
• W3030876242 hasConceptScore W3030876242C38180746 @default.
• W3030876242 hasConceptScore W3030876242C50382708 @default.
• W3030876242 hasConceptScore W3030876242C71924100 @default.
• W3030876242 hasConceptScore W3030876242C90924648 @default.
• W3030876242 hasIssue "11" @default.
• W3030876242 hasLocation W30308762421 @default.
• W3030876242 hasOpenAccess W3030876242 @default.
• W3030876242 hasPrimaryLocation W30308762421 @default.
• W3030876242 hasRelatedWork W1230106424 @default.
• W3030876242 hasRelatedWork W1537764476 @default.
• W3030876242 hasRelatedWork W1554545056 @default.
• W3030876242 hasRelatedWork W1978604553 @default.
• W3030876242 hasRelatedWork W2015658158 @default.
• W3030876242 hasRelatedWork W2039176416 @default.
• W3030876242 hasRelatedWork W2123034797 @default.
• W3030876242 hasRelatedWork W2416366255 @default.
• W3030876242 hasRelatedWork W2471125883 @default.
• W3030876242 hasRelatedWork W2573436643 @default.
• W3030876242 hasRelatedWork W2599515504 @default.
• W3030876242 hasRelatedWork W2803724821 @default.
• W3030876242 hasRelatedWork W2907448573 @default.
• W3030876242 hasRelatedWork W2952635770 @default.
• W3030876242 hasRelatedWork W2972083722 @default.
• W3030876242 hasRelatedWork W3024424389 @default.
• W3030876242 hasRelatedWork W3025132448 @default.
• W3030876242 hasRelatedWork W3161692089 @default.
• W3030876242 hasRelatedWork W3186252886 @default.
• W3030876242 hasRelatedWork W3186879566 @default.
• W3030876242 hasVolume "45" @default.
• W3030876242 isParatext "false" @default.
• W3030876242 isRetracted "false" @default.
• W3030876242 magId "3030876242" @default.
• W3030876242 workType "article" @default.