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- W3030890711 abstract "ObjectiveThe aim of this study was to evaluate the β-cell mass (BCM) in patients with type 2 diabetes mellitus(T2D) by PET/CT using [18F]-FP-(+ )-DTBZ, which is a vesicular monoamine transporter type 2 molecular probe. The feasibility of pancreatic head, body and tail as the target area was investigated for evaluation of the BCM in T2D.Methods15 subjects (8 with T2D, and 7 as control) were involved in this study with 20 min static PET imaging at 40 min post injection of [18F]-FP-(+ )-DTBZ. The volume of interest (VOIs) of pancreatic head, body and tail were drawn and quantitatively assessed. Spleens were collected as reference tissue for SUVR calculation.ResultsSUVR in the pancreatic head (SUVR=1.72±0.47) and pancreatic body, tail (SUVR=1.85±0.41) in T2D group was no significant difference, and no significant difference was observed in the pancreatic head (SUVR=2.54±0.57) and pancreatic body, tail(SUVR=2.73±0.41) in control group as well. In T2D group, a significant decreased SUVR was found in pancreatic head (P=0.008 8) and pancreatic body and tail (P=0.001 2) compared with controls.ConclusionThe VMAT2 molecular probe [18F]-FP-(+ )-DTBZ can be used to evaluate BCM in patients with T2D. (Chin J Endocrinol Metab, 2018, 34: 638-642)Key words: Diabetes mellitus; Positron emission tomography; β-cell mass; VMAT2" @default.
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- W3030890711 date "2018-08-25" @default.
- W3030890711 modified "2023-09-27" @default.
- W3030890711 title "Evaluation of β-cell mass in type 2 diabetic patients with [18F]-FP-(+ )-DTBZ, a vesicular monoamine transporter type 2 molecular probe" @default.
- W3030890711 doi "https://doi.org/10.3760/cma.j.issn.1000-6699.2018.08.003" @default.
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