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- W3030897430 abstract "Objective To investigate the expression of neutrophil gelatinase-associated lipocalin(NGAL) in the urine and plasma of type-2 diabetes patients,to analyze the value of the fractional excretion rate of NGAL(Fe NGAL).Methods 118 cases with T2DM and 28 control subjects wereselected.The DM cases were divided into 3 groups according to urine albumin/creatinine ratio(UACR):64cases in normal albuminuria group,36 cases in microalbuminuria group,and 18 cases in macroalbuminuria group,respectively.Urinary and plasma NGAL were measured by ELISA.Fasting glucose,serum cystatin C(Cysc),glycohemoglobinA1c (HbA1c) were also measured.Fe NGAL was determined by Bolignano D formulae; Glomerular filtration rate (GFR) determined by Macisaac formulae.Results (1)Fe NGAL in T2DM was significantly higher,comparing with the controls; significant difference was also found among the three groups ( P＜0.05 ).(2) Fe NGAL was positively corelated with Cys C and UACR(R=0.279,0.485),but inversely corelated with GFR(R=-0.235).Conclusion Fe NGAL can reflect the damage of T2DM earlier than urine albumin or Urinary NGAL.Key words: Diabetes mellitus; Diabetic nephropathy; Neutrophil gelatinase-associated lipocalin ( NGAL ); The fractional excretion rate of NGAL(Fe NGAL)" @default.
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- W3030897430 date "2011-10-15" @default.
- W3030897430 modified "2023-09-27" @default.
- W3030897430 title "The clinic value of the fractional excretion rate of NGAL in type-2 diabetes patients" @default.
- W3030897430 doi "https://doi.org/10.3760/cma.j.issn.1007-1245.2011.20.001" @default.
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