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- W3030903575 abstract "ObjectiveTo understand the incidence and risk factors of warfarin related hemorrhagic events during anticoagulation therapy with warfarin in patients with cirrhosis and portal vein thrombosis(PVT) after transjugular intrahepatic portosystemic shunt (TIPS).MethodsThe patients with liver cirrhosis who were treated with warfarin after TIPS due to portal hypertension were followed up from January 2012 in Xijing Hospital of Digestive Diseases, Air Force Military Medical University. The data of medical records and follow-up records up to the end of December 2015 in patients undergoing TIPS were collected and retrospectively analyzed. Cumulative incidence of hemorrhagic events related to warfarin treatment was calculated by Kaplan-Meier method. The patients were divided into warfarin-related bleeding group (bleeding group) and non warfarin-related bleeding group (non-bleeding group). The risk factors of hemorrhagic events related to warfarin treatment were analyzed using Cox regression model and the hazard ratio (HR) and the 95% confidence interval (CI) were calculated.ResultsA total of 179 patients were enrolled, including 117 males and 62 females with ages of 25-79 years and average age of (52±12) years; the bleeding group comprised 47 patients (26.3%) and the non-bleeding group comprised 132 patients (73.7%). The follow-up time after discharge ranged 1-74 months and the average time was (28±21) months. The average portal pressure gradient dropped from (25.4±5.2) to (8.7±3.7) mmHg before and after TIPS (P 115 μmol/L was an independent risk factor for hemorrhagic events related to warfarin treatment (HR=1.82, 95%CI: 1.01-3.28, P=0.045).ConclusionsIt is relatively safe for patients with liver cirrhosis and PVT receiving warfarin anticoagulation therapy after TIPS. Elevated serum creatinine is an independent risk factor for hemorrhagic events related to warfarin treatment.Key words: Cirrhosis; Portasystemic shunt, transjugular intrahepatic; Warfarin; Hemorrhage" @default.
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- W3030903575 date "2018-08-28" @default.
- W3030903575 modified "2023-09-22" @default.
- W3030903575 title "Analysis on incidence and risk factors of hemorrhagic events during anticoagulation therapy with warfarin in patients with liver cirrhosis and portal vein thrombosis after trans-jugular intrahepatic portosystemic shunt" @default.
- W3030903575 doi "https://doi.org/10.3760/cma.j.issn.1008-5734.2018.04.004" @default.
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