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- W3030908838 abstract "表观遗传学涉及的机制主要包括DNA甲基化和组蛋白修饰及染色质重塑.这些因素共同构成基因的微环境来调控基因的转录.DNA的低甲基化可能在异常组蛋白修饰的协同下引起某些T细胞基因的异常活化,导致狼疮自身免疫的发生.目前认为,信号转导和转录调节蛋白的异常是与之相关的两个可能因素。" @default.
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- W3030908838 date "2006-11-15" @default.
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- W3030908838 title "The Epigenetic Pathogenesis of Systemic Lupus Erythematosus" @default.
- W3030908838 doi "https://doi.org/10.3760/cma.j.issn.1673-4173.2006.06.009" @default.
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