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• W3030917074 abstract "ObjectiveTo investigate the effect of anti-inlammation and antiulcer in rats of Erkou powder and Erkou film.MethodsThe rats were divided into six groups according to random number table: control group, Guilin watermelon frost group, Erkou powder low dose group, Erkou powder high dose group, Erkou film low dose group and Erkou film high dose group, each with 12. Guilin watermelon frost group was given 0.7 g/kg, Ekou powder low dose group and high dose group were respectively given 14.56, 29.12 mg/kg, Erkou film low dose group and high dose group were given 19.25, 38.5 mg/kg by intragastric administration. Control group was given the same volume of normal sodium by intragastric administration. To observe the inhibitory actions of paw edema induced by carrageenan of big rats, the increase of abdominal cavity capillary permeability in rats due to acetic acid and effect of oral ulcer healing on aceti acid-cautery type oral ulcer rats.ResultsCompared with the control group, 1 h and 3 h after injection of 1% carrageenan, the paw edema of rats were significantly reduced in Guilin watermelon frost group, Erkou powder high dose group and Erkou film high dose group (P<0.01 or P<0.05). Compared with the control group, the absorbance (0.62 ± 0.08, 0.62 ± 0.17, 0.64 ± 0.15 vs. 0.82 ± 0.24) of peritoneal lavage fluid in Guilin watermelon frost group, Erkou powder high dose group and Erkou film high dose group were significantly decreased (P<0.05). Compared with the control group, the diameter of ulcer area (3.16 ± 0.68 mm, 3.12 ± 0.45 mm, 3.22 ± 0.59 mm, 3.23 ± 0.70 mm vs. 3.90 ± 0.72 mm) of rat in Guilin watermelon frost group, Erkou powder low dose group, Erkou powder high dose group and Erkou film high dose group were significantly decreased (P<0.01 or P<0.05) in the third day. Compared with the control group, the diameter of ulcer area (1.93 ± 0.49 mm, 1.39 ± 0.42 mm, 2.01 ± 0.45 mm, 1.98 ± 0.61 mm vs. 2.69 ± 0.74 mm) of rat in Guilin watermelon frost group, Erkou powder low dose group, Erkou powder high dose group and Erkou film high dose group were significantly decreased (P<0.01 or P<0.05) in the fifth day. Compared with the control group, the healing time of oral ulcer (7.20 ± 0.67 d, 6.64 ± 0.67 d, 7.27 ± 0.90 d, 7.27 ± 0.90 d vs. 8.37 ± 1.12 d) of rat in Guilin watermelon frost group, Erkou powder low dose group, Erkou powder high dose group and Erkou film high dose group were significantly shortened.ConclusionsBoth Erkou plastics and Erkou powder have the effects of resisting inflammation and promoting the healing of oral ulcers.Key words: Oral ulcer; Inflammation; Erkou powder; Erkou plastics; Rats" @default.
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• W3030917074 date "2018-09-30" @default.
• W3030917074 modified "2023-09-24" @default.
• W3030917074 title "Study on anti-inlammation activity and antiulcer effects of Erkou powder and Erkou film" @default.
• W3030917074 doi "https://doi.org/10.3760/cma.j.issn.1673-4246.2018.09.014" @default.
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