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- W3030930446 abstract "目的 探讨灯盏花对大鼠急性呼吸窘迫综合征(ARDS)中细胞凋亡的作用及可能机制.方法 建立大鼠在体ARDS模型,将32只大鼠按随机数字表法分为对照组(I组)、ARDS组(II组)、小剂量灯盏花组(III组,25 mg/kg)和大剂量灯盏花组(IV组,50 mg/kg),检测各组肺组织超氧化物歧化酶(SOD)活性、丙二醛(MDA)含量,应用免疫组化法检测bcl-2蛋白含量,DNA缺口末端标记法(TUNEL)检测肺细胞凋亡,光镜下HE染色观察病理形态学改变.结果 与II组比较,III、IV组SOD活性及bcl-2含量明显增高,MDA含量、凋亡指数均明显降低,肺水肿程度显著减轻;III、IV组之间比较差异有统计学意义(P＜0.05).结论 灯盏花对ARDS具有防治作用,其机制可能与抗氧化、抑制氧自由基释放、上调bcl-2基因表达,从而减轻肺细胞凋亡有关.大剂量比小剂量保护作用更显著。" @default.
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- W3030930446 date "2013-12-20" @default.
- W3030930446 modified "2023-09-25" @default.
- W3030930446 title "Effects of erigeron breviscapine on pneumocyte apoptosis during acute respiratory distress syndrome in rats" @default.
- W3030930446 doi "https://doi.org/10.3760/cma.j.issn.1008-1372.2013.12.004" @default.
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