Matches in SemOpenAlex for { <https://semopenalex.org/work/W3030947573> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W3030947573 endingPage "368" @default.
- W3030947573 startingPage "363" @default.
- W3030947573 abstract "Objective To assess the roles of phosphoinositide 3 kinase/serine-threonine kinase(PI3K/Akt) signal pathway in cardioprotection of fentanyl postconditioning and limb remote postconditioning in an in vivo rat model with myocardial ischemia reperfusion injury.Methods Thirty-two anesthetized male SD rats (weighed 250 g-350 g) were randomly allocated into the four groups:group C (control),group F (fentanyl postconditioning),group R (RIPOC),and group F-R (combined fentanyl postconditioning and RIPOC).All rats were treated with left anterior descending coronary artery(LAD) occluded for 30 min,followed by a 60-min reperfusion (LAD open) in vivo.The Olingo PI3k/Akt signaling pathway microarray (SA Bioscience)and Western-blot technique were used to distinguish the expression of genes related to PI3K/Akt pathway and levels of phosphorylated Akt in myocardial tissue sample from ischemia area.Results Expressions of many detected genes relating to PI3K/Akt signal pathway were significantly different among the four groups.As compared with group C,9 genes showed a significant up-regulated expression in group F,2 genes showed a significant up-regulated expression in group R,and a total number of 33 genes showed a significant up-regulated expression in group F-R.The Western-blot analysis revealed that the expression of phosphorylated Akt in myocardium increased significantly in groups F,R and F-R compared with group C.The expression of phosphorylated Akt in myocardium was also stronger in group F -R than in groups F and R.Conclusions Combined fentanyl postconditioning and RIPOC can produce an enhanced activation of PI3K/Akt signal pathway.Key words: Myocardial ischemia/reperfusion injury; Cardioprotection; Remote ischemia postconditioning; Pharmacological postconditioning; Opioid; Phosphoinositide 3 kinase/serine-threonine kinase signal pathway" @default.
- W3030947573 created "2020-06-05" @default.
- W3030947573 creator A5035418730 @default.
- W3030947573 creator A5077107791 @default.
- W3030947573 date "2012-06-15" @default.
- W3030947573 modified "2023-09-23" @default.
- W3030947573 title "Roles of phosphoinositide 3 kinase/serine -threonine kinase signal pathway in cardioprotection of fentanyl postconditioning and limb remote postconditioning" @default.
- W3030947573 doi "https://doi.org/10.3760/cma.j.issn.1673-4378.2012.06.001" @default.
- W3030947573 hasPublicationYear "2012" @default.
- W3030947573 type Work @default.
- W3030947573 sameAs 3030947573 @default.
- W3030947573 citedByCount "0" @default.
- W3030947573 crossrefType "journal-article" @default.
- W3030947573 hasAuthorship W3030947573A5035418730 @default.
- W3030947573 hasAuthorship W3030947573A5077107791 @default.
- W3030947573 hasConcept C104317684 @default.
- W3030947573 hasConcept C11960822 @default.
- W3030947573 hasConcept C126322002 @default.
- W3030947573 hasConcept C184235292 @default.
- W3030947573 hasConcept C185592680 @default.
- W3030947573 hasConcept C2776415932 @default.
- W3030947573 hasConcept C2779676291 @default.
- W3030947573 hasConcept C2781072394 @default.
- W3030947573 hasConcept C541997718 @default.
- W3030947573 hasConcept C55493867 @default.
- W3030947573 hasConcept C62478195 @default.
- W3030947573 hasConcept C71924100 @default.
- W3030947573 hasConcept C75217442 @default.
- W3030947573 hasConcept C86554907 @default.
- W3030947573 hasConcept C98274493 @default.
- W3030947573 hasConceptScore W3030947573C104317684 @default.
- W3030947573 hasConceptScore W3030947573C11960822 @default.
- W3030947573 hasConceptScore W3030947573C126322002 @default.
- W3030947573 hasConceptScore W3030947573C184235292 @default.
- W3030947573 hasConceptScore W3030947573C185592680 @default.
- W3030947573 hasConceptScore W3030947573C2776415932 @default.
- W3030947573 hasConceptScore W3030947573C2779676291 @default.
- W3030947573 hasConceptScore W3030947573C2781072394 @default.
- W3030947573 hasConceptScore W3030947573C541997718 @default.
- W3030947573 hasConceptScore W3030947573C55493867 @default.
- W3030947573 hasConceptScore W3030947573C62478195 @default.
- W3030947573 hasConceptScore W3030947573C71924100 @default.
- W3030947573 hasConceptScore W3030947573C75217442 @default.
- W3030947573 hasConceptScore W3030947573C86554907 @default.
- W3030947573 hasConceptScore W3030947573C98274493 @default.
- W3030947573 hasIssue "06" @default.
- W3030947573 hasLocation W30309475731 @default.
- W3030947573 hasOpenAccess W3030947573 @default.
- W3030947573 hasPrimaryLocation W30309475731 @default.
- W3030947573 hasRelatedWork W2037306588 @default.
- W3030947573 hasRelatedWork W2051395511 @default.
- W3030947573 hasRelatedWork W2107546876 @default.
- W3030947573 hasRelatedWork W2148468022 @default.
- W3030947573 hasRelatedWork W2354944236 @default.
- W3030947573 hasRelatedWork W2357169709 @default.
- W3030947573 hasRelatedWork W2359293829 @default.
- W3030947573 hasRelatedWork W2370846735 @default.
- W3030947573 hasRelatedWork W2588148232 @default.
- W3030947573 hasRelatedWork W2589004739 @default.
- W3030947573 hasRelatedWork W2974826725 @default.
- W3030947573 hasRelatedWork W3002224833 @default.
- W3030947573 hasRelatedWork W3028650351 @default.
- W3030947573 hasRelatedWork W3029316445 @default.
- W3030947573 hasRelatedWork W3030032227 @default.
- W3030947573 hasRelatedWork W3032121034 @default.
- W3030947573 hasRelatedWork W3032784506 @default.
- W3030947573 hasRelatedWork W3032799783 @default.
- W3030947573 hasRelatedWork W3032854751 @default.
- W3030947573 hasRelatedWork W3182846839 @default.
- W3030947573 hasVolume "33" @default.
- W3030947573 isParatext "false" @default.
- W3030947573 isRetracted "false" @default.
- W3030947573 magId "3030947573" @default.
- W3030947573 workType "article" @default.