FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3030953262> ?p ?o ?g. }

• W3030953262 endingPage "159" @default.
• W3030953262 startingPage "156" @default.
• W3030953262 abstract "Objective To detect the expressions of hTERT and MMP-7 mRNA in the peripheral blood of patients with colorectal cancer and their correlation,and discuss the clinical significance of peripheral blood micro-metastasis.Methods Total RNA was extracted from blood samples by TRIzol and was reverse transcribed into cDNA.The mRNA expressions of MMP-7 and hTERT were detected by real-time PCR.Results Positive mRNA expression of hTERT was found in 63 of 181 patients with colorectal cancer,while positive mRNA expression of MMP-7 was seen in 61 cases.The positive rates of hTERT and MMP-7 mRNA had no significant differences in the patients' sex and age (P ＞ 0.05).The positive rate of MMP-7 mRNA in the patients with poorly differentiated adenocarcinoma (43.9 ％) was higher than that in the patients with moderately and well differentiated adenocarcinoma (27.8 ％) (x2 =4.873,P ＜ 0.05).The positive rate of HTERT mRNA in the patients with stage Ⅲ-Ⅳ (42.5 ％) was higher than that in the patients with stage Ⅰ-Ⅱ (24.0 ％) (x2 =6.591,P ＜ 0.05).The positive rate of MMP-7 mRNA in the patients with stage Ⅲ-Ⅳ (39.6 ％) was higher than that in the patients with stage Ⅰ-1Ⅱ (25.3 ％) (x2 =4.014,P ＜ 0.05).The positive rate of hTERT mRNA in the patients with distant metastasis (53.3 ％) was higher than that in the patients without distant metastasis (28.7 ％) (x2 =9.059,P ＜ 0.05).The positive rate of MMP-7 mRNA in the patients with distant metastasis(46.7 ％) was higher than that in the patients without distant metastasis (29.4 ％) (x2 =4.506,P ＜ 0.05).The positive rate of hTERT mRNA in the patients with positive CEA expression (52.6 ％) was significantly higher than that in the patients with negative CEA expression (30.1％) (x2 =6.735,P ＜ 0.05).The positive rate of MMP-7mRNA in the patients with positive CEA expression (60.5 ％) was significantly higher than those in the patients with negative CEA expression (26.6 ％) (x2 =15.490,P ＜ 0.05).In the patients without distant metastasis,any of hTERT and MMP-7 mRNA expression was thought to be blood micro-metastasis.The recurrence and metastasis rates after 6 months in the patients with blood micrometastasis (36.58 ％) were higher than those in the patients without blood micro-metastasis (7.14 ％)(x2 =13.027,P ＜ 0.05).The recurrence and metastasis rates after 12-month follow-up in the patients with blood micro-metastasis (68.29 ％) were higher than those in the patients without blood micro-metastasis (12.5 ％) (x2 =31.948,P ＜ 0.01).The sensitivity of combined detection was 80.00 ％,and the specificity was 79.03 ％ after 12-month follow-up.Spearman correlation analysis revealed that significant positive correlation existed between hTERT and MMP-7mRNA expression (r =0.341,P =0.000).Conclusion Detection of hTERT and MMP-7 mRNA expression can be used as reliable markers to predict peripheral blood micrometastasis in colorectal cancer patients.Key words: Colorectal neoplasms;  Human telomerase tranacripyase;  Matrix metalloproteinase; Reverse transcriptosw polymerase chin reaction" @default.
• W3030953262 created "2020-06-05" @default.
• W3030953262 creator A5003939083 @default.
• W3030953262 creator A5013890694 @default.
• W3030953262 creator A5029687127 @default.
• W3030953262 creator A5037414724 @default.
• W3030953262 creator A5065715690 @default.
• W3030953262 creator A5074795414 @default.
• W3030953262 date "2013-03-28" @default.
• W3030953262 modified "2023-10-03" @default.
• W3030953262 title "mRNA expressions of hTERT and MMP-7 in the peripheral blood of patients with colorectal cancer and their correlation" @default.
• W3030953262 doi "https://doi.org/10.3760/cma.j.issn.1006-9801.2013.03.004" @default.
• W3030953262 hasPublicationYear "2013" @default.
• W3030953262 type Work @default.
• W3030953262 sameAs 3030953262 @default.
• W3030953262 citedByCount "0" @default.
• W3030953262 crossrefType "journal-article" @default.
• W3030953262 hasAuthorship W3030953262A5003939083 @default.
• W3030953262 hasAuthorship W3030953262A5013890694 @default.
• W3030953262 hasAuthorship W3030953262A5029687127 @default.
• W3030953262 hasAuthorship W3030953262A5037414724 @default.
• W3030953262 hasAuthorship W3030953262A5065715690 @default.
• W3030953262 hasAuthorship W3030953262A5074795414 @default.
• W3030953262 hasConcept C104317684 @default.
• W3030953262 hasConcept C105580179 @default.
• W3030953262 hasConcept C121608353 @default.
• W3030953262 hasConcept C125593758 @default.
• W3030953262 hasConcept C126322002 @default.
• W3030953262 hasConcept C143998085 @default.
• W3030953262 hasConcept C146357865 @default.
• W3030953262 hasConcept C151730666 @default.
• W3030953262 hasConcept C2779013556 @default.
• W3030953262 hasConcept C2781182431 @default.
• W3030953262 hasConcept C3019926457 @default.
• W3030953262 hasConcept C502942594 @default.
• W3030953262 hasConcept C526805850 @default.
• W3030953262 hasConcept C55493867 @default.
• W3030953262 hasConcept C71924100 @default.
• W3030953262 hasConcept C86803240 @default.
• W3030953262 hasConcept C90924648 @default.
• W3030953262 hasConcept C94581717 @default.
• W3030953262 hasConceptScore W3030953262C104317684 @default.
• W3030953262 hasConceptScore W3030953262C105580179 @default.
• W3030953262 hasConceptScore W3030953262C121608353 @default.
• W3030953262 hasConceptScore W3030953262C125593758 @default.
• W3030953262 hasConceptScore W3030953262C126322002 @default.
• W3030953262 hasConceptScore W3030953262C143998085 @default.
• W3030953262 hasConceptScore W3030953262C146357865 @default.
• W3030953262 hasConceptScore W3030953262C151730666 @default.
• W3030953262 hasConceptScore W3030953262C2779013556 @default.
• W3030953262 hasConceptScore W3030953262C2781182431 @default.
• W3030953262 hasConceptScore W3030953262C3019926457 @default.
• W3030953262 hasConceptScore W3030953262C502942594 @default.
• W3030953262 hasConceptScore W3030953262C526805850 @default.
• W3030953262 hasConceptScore W3030953262C55493867 @default.
• W3030953262 hasConceptScore W3030953262C71924100 @default.
• W3030953262 hasConceptScore W3030953262C86803240 @default.
• W3030953262 hasConceptScore W3030953262C90924648 @default.
• W3030953262 hasConceptScore W3030953262C94581717 @default.
• W3030953262 hasIssue "03" @default.
• W3030953262 hasLocation W30309532621 @default.
• W3030953262 hasOpenAccess W3030953262 @default.
• W3030953262 hasPrimaryLocation W30309532621 @default.
• W3030953262 hasRelatedWork W2073454518 @default.
• W3030953262 hasRelatedWork W2355781930 @default.
• W3030953262 hasRelatedWork W2364709123 @default.
• W3030953262 hasRelatedWork W2365969528 @default.
• W3030953262 hasRelatedWork W2367705470 @default.
• W3030953262 hasRelatedWork W2367879410 @default.
• W3030953262 hasRelatedWork W2372644828 @default.
• W3030953262 hasRelatedWork W2374814928 @default.
• W3030953262 hasRelatedWork W2380402332 @default.
• W3030953262 hasRelatedWork W2385280617 @default.
• W3030953262 hasRelatedWork W2386567258 @default.
• W3030953262 hasRelatedWork W2387918560 @default.
• W3030953262 hasRelatedWork W2394100062 @default.
• W3030953262 hasRelatedWork W2403192691 @default.
• W3030953262 hasRelatedWork W2413446752 @default.
• W3030953262 hasRelatedWork W2588492615 @default.
• W3030953262 hasRelatedWork W3028665487 @default.
• W3030953262 hasRelatedWork W3028969834 @default.
• W3030953262 hasRelatedWork W3031008415 @default.
• W3030953262 hasRelatedWork W3195180877 @default.
• W3030953262 hasVolume "25" @default.
• W3030953262 isParatext "false" @default.
• W3030953262 isRetracted "false" @default.
• W3030953262 magId "3030953262" @default.
• W3030953262 workType "article" @default.