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- W3030962694 abstract "目的研究SiO2刺激肺泡巨噬细胞(PAM)培养基上清液对肺成纤维细胞连接蛋白Cx43定位的影响,以深入探索SiO2抑制肺成纤维细胞间隙连接通讯(GJIC)的作用水平.方法用0～500μg/mlSiO2刺激PAM和佛波酯(TPA)诱导分化的THP-1(TPA-primed THP-1,pTHP-1)细胞(具有PAM特性的人血单核细胞株)的培养上清液对培养的中国仓鼠肺成纤维细胞(CHL)作用24 h,采用间接免疫荧光细胞化学法和激光共聚焦扫描显微镜(LCSM)进行连接蛋白Cx43定位的测定.结果正常对照组相邻细胞连接处有明亮的斑片状标记,聚集分布连接成线;SiO2刺激PAM和pTHP-1细胞培养上清液作用的CHL细胞连接处标记斑点逐渐减少,Cx43蛋白标记斑点出现在胞浆内,呈无特异性定位状态;随着SiO2剂量的增加,细胞内Cx43蛋白标记斑点向细胞核聚集.结论SiO2刺激PAM和pTHP-1细胞培养上清液可以改变肺成纤维细胞Cx43蛋白的定位.推测SiO2抑制成纤维细胞GJIC功能可能与细胞连接蛋白Cx43的内移有关." @default.
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- W3030962694 date "2001-09-20" @default.
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- W3030962694 title "Localization of the connexin 43 gap-junction protein in silicon dioxide exposed to pulmonary fibroblasts" @default.
- W3030962694 doi "https://doi.org/10.3760/cma.j.issn.1001-9391.2001.05.011" @default.
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