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• W3030964826 abstract "ObjectiveTo investigate the protective effect of hyperbaric oxygen (HBO) on the cognitive impairment caused by severe heat stroke (HS).Methods60 male Sprague-Dawley rats were randomly divided to the control group, the HS group, the HBO group, the hyperbaric air (HBA) group, the HS+ HBO group and HS+ HBA group, each group had 10 rats. The rats were exposed to 40℃ heat chamber. When the core temperature reached 42℃, they were taken out as the onset of severe heatstroke. Rats in HS+ HBO and HBO groups were placed in the hyperbaric chambers with pure oxygen at 2.5ATA for 60 min while HS+ HBA and HBA rats were placed with air. Cognitive functions were tested by Morris water maze. The pathology of hippocampus, neurological function scoreand the mortality rates were evaluated among different groups.ResultsThe escape latency time and distance was significantly increased in the HS group compared with control group [(45.84±0.13) s vs (22.16±1.40) s, t=-2.4, P=0.04; (815.7±36.8) cm vs (177.71±21.00) cm, t=-3.3, P=0.01]; the number of platform-crossing and the activity time of target quadrant was significantly reduced in the HS group compared with control [(1.90±0.16) times vs (5.80±0.20) times, t=3.7, P=0.04; (32.12±0.19)% vs (57.12±1.60)%, t=2.8, P=0.020]. HBO reduced the escape latency time [(30.21±1.50) s] and distance [(165.58±7.04) cm] significantly, and HBO increased the number of platform-crossing [(4.40±0.18) times] and the activity time of target quadrant [(41.87±1.17)%] significantly. HBO alleviated the injury to hippocampus in pathological observation, reduced the mNSS scores 2 and 24 hours after HS [2 h: (7.70±0.42) scores vs (9.60±0.31) scores, t=6.3, P=0.00; 24 h: (3.90±0.20) scores vs (5.60±0.23) scores, t=2.4, P=0.02] and the mortality rate of HS (20.0% vs 40.0%, P=0.08). There was no significant change in HS+ HBA group compared with HS group, and there was no significant changes in HBO group and HBA group compared with Control group.ConclusionHBO may alleviate the cognitive impairment which caused by HS through the protective effects of hippocampus.Key words: Severe heat stroke; Hyperbaric oxygen; Brain injury; Cognitive dysfunction" @default.
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• W3030964826 date "2018-11-28" @default.
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• W3030964826 title "Protective effect of hyperbaric oxygen to thecognitive impairment caused by severe heatstroke in a rat model" @default.
• W3030964826 doi "https://doi.org/10.3877/cma.j.issn.2096-1537.2018.04.011" @default.
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