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- W3030979423 abstract "目的 通过对不同雌激素水平大鼠进行膀胱功能、组织形态和超微结构的比较,探讨雌激素对膀胱功能的影响及其作用机制.方法 30只雌性成年SD大鼠均分为3组:OVX+E组(切除双侧卵巢后补充戊酸雌二醇0.8 mg·kg-1·d-1,溶于0.5%羧甲基纤维素钠,每日灌胃1次)、OVX组(切除双侧卵巢)、正常对照组(未切除卵巢),后两组大鼠每日给予0.5%羧甲基纤维素钠灌胃1次.3组大鼠用药12周后行膀胱压力容积测定,并用切除膀胱的石蜡切片分析胶原纤维和平滑肌的面密度及两者比值,透射电镜下观察逼尿肌的超微结构.结果 (1)OVX组膀胱最大容量(0.32±0.20)ml、顺应性(0.012±0.006)ml/cm H2O(1 cm H2O＝0.098 kPa)和最大收缩力(1.4±0.4)cm H2O,相对于正常对照组[分别为(1.11±0.09)ml、(0.026±0.003)ml/cm H2O和(4.4±0.3) cm H2O]明显减少,差异均有统计学意义(P＜0.05).OVX+E组膀胱最大容量为(0.83±0.10)ml,相对于正常对照组减少(P＜0.05),而膀胱顺应性(0.029±0.003)ml/cm H2O、最大收缩力(4.8±1.4)cm H2O与正常对照组比较,差异无统计学意义(P＞0.05).(2)胶原纤维面密度、胶原纤维面密度/平滑肌面密度比值,OVX组分别为0.218±0.041和0.54±0.08,相对于正常对照组(0.160±0.039、0.32±0.09)明显增加,差异有统计学意义(P＜0.05);而OVX+E组(0.178±0.027、0.38±0.06)与正常对照组比较,差异无统计学意义(P＞0.05).(3)电镜观察OVX组逼尿肌超微结构出现退行性改变,其他两组无类似变化.结论 大鼠切除双侧卵巢后膀胱功能明显降低,补充雌激素有利于改善膀胱功能,这一作用可能是通过抑制胶原增生,保护细胞器来实现的。" @default.
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- W3030979423 date "2006-12-25" @default.
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- W3030979423 title "Effect of ovariectomy and estrogen replacement on bladder function and structure in rats" @default.
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