FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3030980831> ?p ?o ?g. }

• W3030980831 endingPage "283" @default.
• W3030980831 startingPage "279" @default.
• W3030980831 abstract "Objective To investigate the expression and clinical significance of heat shock transcription factor 1 (HSF1) protein in human hepatocellular carcinoma (HCC) tissues,and deduce the probable molecular mechanism of HSF1 in the development and advancement of HCC.Methods Sixty-seven samples of HCC tissue and 21 samples of normal liver tissue were obtained from March 2006 to March 2007 at the Xijing Hospital.The expressions of HSF1 protein and heat shock protein 70 (HSP70) were detected by using immunohistochemistry.The probable molecular mechanism of HSF1 in the development and advancement of HCC was deduced according to the relationship between the expressions of HSF1 protein and HSP70.Positive rates of HSF1 protein in different tissues and the relationship between HSF1 protein expression in the HCC tissues and clinical pathological factors were analyzed by the chi-square test and by calculating Fisher exact probability,respectively.The correlation between the expressions of HSF1 protein and HSP70 in the HCC tissue was analyzed by the Spearman correlation coefficient.The survival curve was drawn by the Kaplan-Meier method,and the survival rate was analyzed by the Log-rank test.Results The positive rates of HSF1 protein expression was 69％ (46/67) in the HCC tissue,which was significantly higher than 29％ (6/21) in the normal liver tissue ( x2 =10.628,P ＜ 0.05 ),The positive rates of HSP70 expression in the HCC tissue was 57％ (38/67),which was significantly higher than 24％ (5/21) in the normal liver tissue ( x2 =6.929,P ＜ 0.05 ).The expression of HSF1 protein in the HCC tissue was positively correlated with that of HSP70 (r=0.319,P ＜0.05).The high expression of HSF1 protein was correlated with the integrity of capsule of HCC,tumor differentiation and TNM stage (x2 =5.935,9.762,5.159,11.267,P＜0.05 ),while the high expression of HSF1 protein was not correlated with the gender,age,levels of hepatitis B surface antigen and alpha fetoprotein,and portal vein tumor thrombus ( x2 =0.822,0.172,2.059,P ＞0.05 ).The survival time was (21.4 ± 1.9 )months for patients with positive HSF1 protein expression and (29.8 ± 2.7 ) months for patients with negative HSF1 protein expression.There was a significant difference in the survival time between patients with positive and negative HSF1 protein expression ( x2 =4.276,P ＜ 0.05 ).Conclusions HSF1 is correlated with the development,advancement,invasion,metastasis and malignant prognosis of HCC.HSF1 takes effects by regulating the expression of HSP70,and it has a good perspective of clinical application for the diagnosis and treatment of HCC.Key words: Liver neoplasms; Heat shock transcription factor 1; Heat shock protein 70; Immunohistochemistry" @default.
• W3030980831 created "2020-06-05" @default.
• W3030980831 creator A5009700292 @default.
• W3030980831 creator A5028349459 @default.
• W3030980831 creator A5031504820 @default.
• W3030980831 creator A5060249948 @default.
• W3030980831 date "2012-06-20" @default.
• W3030980831 modified "2023-09-23" @default.
• W3030980831 title "Expression and clinical significance of heat shock transcription factor 1 protein in human hepatocellular carcinoma tissues" @default.
• W3030980831 doi "https://doi.org/10.3760/cma.j.issn.1673-9752.2012.03.023" @default.
• W3030980831 hasPublicationYear "2012" @default.
• W3030980831 type Work @default.
• W3030980831 sameAs 3030980831 @default.
• W3030980831 citedByCount "0" @default.
• W3030980831 crossrefType "journal-article" @default.
• W3030980831 hasAuthorship W3030980831A5009700292 @default.
• W3030980831 hasAuthorship W3030980831A5028349459 @default.
• W3030980831 hasAuthorship W3030980831A5031504820 @default.
• W3030980831 hasAuthorship W3030980831A5060249948 @default.
• W3030980831 hasConcept C104317684 @default.
• W3030980831 hasConcept C126322002 @default.
• W3030980831 hasConcept C142724271 @default.
• W3030980831 hasConcept C143998085 @default.
• W3030980831 hasConcept C204232928 @default.
• W3030980831 hasConcept C205260736 @default.
• W3030980831 hasConcept C207886595 @default.
• W3030980831 hasConcept C2776667301 @default.
• W3030980831 hasConcept C2778019345 @default.
• W3030980831 hasConcept C502942594 @default.
• W3030980831 hasConcept C52981337 @default.
• W3030980831 hasConcept C55493867 @default.
• W3030980831 hasConcept C68991219 @default.
• W3030980831 hasConcept C71924100 @default.
• W3030980831 hasConcept C86803240 @default.
• W3030980831 hasConceptScore W3030980831C104317684 @default.
• W3030980831 hasConceptScore W3030980831C126322002 @default.
• W3030980831 hasConceptScore W3030980831C142724271 @default.
• W3030980831 hasConceptScore W3030980831C143998085 @default.
• W3030980831 hasConceptScore W3030980831C204232928 @default.
• W3030980831 hasConceptScore W3030980831C205260736 @default.
• W3030980831 hasConceptScore W3030980831C207886595 @default.
• W3030980831 hasConceptScore W3030980831C2776667301 @default.
• W3030980831 hasConceptScore W3030980831C2778019345 @default.
• W3030980831 hasConceptScore W3030980831C502942594 @default.
• W3030980831 hasConceptScore W3030980831C52981337 @default.
• W3030980831 hasConceptScore W3030980831C55493867 @default.
• W3030980831 hasConceptScore W3030980831C68991219 @default.
• W3030980831 hasConceptScore W3030980831C71924100 @default.
• W3030980831 hasConceptScore W3030980831C86803240 @default.
• W3030980831 hasIssue "03" @default.
• W3030980831 hasLocation W30309808311 @default.
• W3030980831 hasOpenAccess W3030980831 @default.
• W3030980831 hasPrimaryLocation W30309808311 @default.
• W3030980831 hasRelatedWork W1999221969 @default.
• W3030980831 hasRelatedWork W2089678974 @default.
• W3030980831 hasRelatedWork W2153854421 @default.
• W3030980831 hasRelatedWork W2347877618 @default.
• W3030980831 hasRelatedWork W2349139862 @default.
• W3030980831 hasRelatedWork W2349322693 @default.
• W3030980831 hasRelatedWork W2352281665 @default.
• W3030980831 hasRelatedWork W2365224344 @default.
• W3030980831 hasRelatedWork W2366633463 @default.
• W3030980831 hasRelatedWork W2371506608 @default.
• W3030980831 hasRelatedWork W2373382307 @default.
• W3030980831 hasRelatedWork W2375740166 @default.
• W3030980831 hasRelatedWork W2376779498 @default.
• W3030980831 hasRelatedWork W2378820334 @default.
• W3030980831 hasRelatedWork W2390510950 @default.
• W3030980831 hasRelatedWork W2393126562 @default.
• W3030980831 hasRelatedWork W2417012489 @default.
• W3030980831 hasRelatedWork W2471778693 @default.
• W3030980831 hasRelatedWork W2561014126 @default.
• W3030980831 hasRelatedWork W208762986 @default.
• W3030980831 hasVolume "11" @default.
• W3030980831 isParatext "false" @default.
• W3030980831 isRetracted "false" @default.
• W3030980831 magId "3030980831" @default.
• W3030980831 workType "article" @default.