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• W3030988365 startingPage "889" @default.
• W3030988365 abstract "The complement system is an ancient arm of the innate immune system that plays important roles in pathogen recognition and elimination. Upon activation by microbes, complement opsonizes bacterial surfaces, recruits professional phagocytes, and causes bacteriolysis. Borreliella species are spirochetal bacteria that are transmitted to vertebrate hosts via infected Ixodes ticks and are the etiologic agents of Lyme disease. Pathogens that traffic in blood and other body fluids, like Borreliella, have evolved means to evade complement. Lyme disease spirochetes interfere with complement by producing a small arsenal of outer-surface lipoproteins that bind host complement components and manipulate their native activities. Here we review the current landscape of complement evasion by Lyme disease spirochetes and provide an update on recent discoveries." @default.
• W3030988365 created "2020-06-05" @default.
• W3030988365 creator A5014066546 @default.
• W3030988365 creator A5067154316 @default.
• W3030988365 date "2020-11-01" @default.
• W3030988365 modified "2023-10-17" @default.
• W3030988365 title "Complement Evasion by Lyme Disease Spirochetes" @default.
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• W3030988365 doi "https://doi.org/10.1016/j.tim.2020.05.004" @default.
• W3030988365 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7572514" @default.

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