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- W3030992275 abstract "ObjectiveTo discuss the increase of white blood cell (WBC) in patients treated with glucocorticoid is due to the increase of the infection, or the increase of the non-infection to improve the accuracy of diagnosis and reduce the abuse of antibiotics.Methods80 patients treated in our hospital from March 2012 to May 2014 were recruited in the study.According to the type of disease and therapies, they were divided into glucocorticoid without infection group (n=20), infection with glucocorticoid group (n=29), and infection without glucocorticoid group (n=31). After treatment with glucocorticoid and (or) antibiotics for 0, 3, 5, 7 d, venous blood samples of patients were collected to determine the concentration of WBC, C-reaction protein (CRP), procalcitonin (PCT), prealbumin (PA) count.Clinical pulmonary infection score (CPIS) was measured before and seventh day after treatment in infection group.ResultsThere was no significant difference in WBC concentration in the 3rd, 5th and 7th day after treatment with corticosteroids between the glucocorticoid without infection group and the infection with glucocorticoid group (all P>0.05). Compared with the infection without glucocorticoid group, WBC was significantly higher and CRP was significantly decreased in the 3rd, 5th and 7th day after treatment with corticosteroids in the infection with glucocorticoid group (all P 0.05).ConclusionsGlucocorticoid can increase venous blood WBC, reduce CRP, but has no significant effection in the PCT, PA and CPIS.PCT, PA and CPIS can be used as references to evaluate the control of infection, the combination of the three indexes can improve the accuracy rate and the specific rate in the diagnosis of infection.Key words: Glucocorticoid; White blood cell; Procalcitonin; C-reaction protein; Prealbumin; Clinical pulmonary infection score" @default.
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- W3030992275 date "2016-09-20" @default.
- W3030992275 modified "2023-09-26" @default.
- W3030992275 title "Relationship between PCT, CRP and increase of white blood cell after application of glucocorticoid" @default.
- W3030992275 doi "https://doi.org/10.3760/cma.j.issn.1673-436x.2016.18.008" @default.
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