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- W3030996811 abstract "The pathophysiology of non-traumatic osteonecrosis of the femoral head is more complex than that of traumatic osteonecrosis, and corticosteroid-induced osteonecrosis presents a huge challenge because of the multiple effects of corticosteroids on multi-system pathways. These pathways include the effects of corticosteroids on osteoblast differentiation, osteoblast and osteoclast apoptosis, lipid metabolism, coagulation pathways, and calcium metabolism. These pathways are frequently interrelated with each other, which makes the pathogenesis even more difficult to understand. Host factors and underlying disease have been shown to play a significant role in the risk of developing osteonecrosis. Identification of genetic variants that convey additional risk will also help to personalize the way we care, both in the prevention and treatment of osteonecrosis.Key words: Glucocorticoids; Femur head necrosis; Therapeutics; Pathogenesis" @default.
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- W3030996811 date "2015-10-01" @default.
- W3030996811 modified "2023-09-23" @default.
- W3030996811 title "Pathogenesis of glucocorticoid-induced osteonecrosis of the femeral head" @default.
- W3030996811 doi "https://doi.org/10.3877/cma.j.issn.1673-9450.2015.05.016" @default.
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