FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3030998889> ?p ?o ?g. }

• W3030998889 endingPage "21" @default.
• W3030998889 startingPage "17" @default.
• W3030998889 abstract "Objective To explore the changes of matrix metalloproteinase-9 and blood brain barrier in cardiopulmonary resuscitation rats and effects of MMP-9 inhibitor on them.Method One hundred and twenty Sprague-Dawley(SD) rats were randomly divided into 3 groups:the sham-operated group,the resuscitation with treatment group and the resuseimfion without treatment group as control.The experiment was made in the animal experiment center of Sun Yat-sen University in Gtlangzhou.The rat eardiopulmonary resuscitation model was made by clipping trachea until asphyxia,and the restoration of spontaneous circulation(ROSC)Was defined by restoration of superventricular rhythm and mean artery pressure (MAP)≥60 mmHg for more than 5 min utes.The rats of sham-operated group were anesahetized only and endotracheal intubation WaS performed.In the resuscitation with treaUnent group ss-3cr(25,ng/ks body weight)Was given intraperitoneally after ROSC.The rats were sacrificed and samples of the brain tissue were taken inmaediately and 3 h,9 h,24 h and 48 h later.After that,the expression of MMP-9 and MMP-9 mRNA in brain tissue were detected.Water oontent and Evans blue in brain tissue Were observed.The uhmmicrostructure of brain tissue was observed under electron microscope.Analysis ofvariance wilE, done with Spssll.0 software.Results 11le expressions of MMP.9 and MMP-9m RNA ofbraintissueiUthe shanloperated group didn't show significant changees in all specimens taken at different intervals and neither the water content and tvans blue did.The Pvalue were 1.0000,0.6831,0.7124 and 0.99r75,respectively.There was no u1.tramicrostruclure change in the sham-operated group.The expressions of MMP_9 and MMP-9 mRNA in the resuscitation control group obviously increased after eardiopulmonary resuscitation,80 did the water content and Evans blue content.Compared with sham-operated group,the P value were 0.0264,0.0163,0.0000 and 0.0412,respee.tively.111e elge of ultmmicrostmeture in the resuscitation control group at different intervals were obvious.The changes of obove biomarkers in the resuscitation treatment group Was siroilar to but less in magnitude than those in the resuscitation control group.The P valHe were 0.0392,0.0373,0.O004 and 0.0180,respectively.Conclusions The expressions of MMP-9 and MMP.9 mRNA obviously increases in the cerebral ischemia model of rats with CPR,and reaches peak at 24 h.Water content and Evans blue content in brain risque obviously increases in the cerebral ischemia model of rats with CPR.BBB iS destroyed.and the peak time iS at 24 h.The injury of ultrami.crostructure of brain tissue under electron microscope iS obvious,and the peak time is at 24 h.The SB-3CT.specif-iC inhibitor of MMP-9 could decrease the expression of MMP-9 and decrease cerebral edema in the cerebral is.chemia modeJ of rats with CPR,and the protection from cerebral isehemia/reperfusion injury after CPR is obvious.Key words: Cardiopulmonary resuscitation; Blood brain barrier; Matrix metallopmteinase; MMP.9 inhibitor; Brmn tissue damage" @default.
• W3030998889 created "2020-06-05" @default.
• W3030998889 creator A5031682845 @default.
• W3030998889 creator A5048198282 @default.
• W3030998889 creator A5066588572 @default.
• W3030998889 creator A5068477955 @default.
• W3030998889 creator A5083455588 @default.
• W3030998889 date "2009-01-10" @default.
• W3030998889 modified "2023-09-24" @default.
• W3030998889 title "Changes of matrix metalloproteinase-9 and blood brain barrier in cardiopulmonary resuscitation rats and effects of MMP-9 inhibitor on them" @default.
• W3030998889 doi "https://doi.org/10.3760/cma.j.issn.1671-0282.2009.01.006" @default.
• W3030998889 hasPublicationYear "2009" @default.
• W3030998889 type Work @default.
• W3030998889 sameAs 3030998889 @default.
• W3030998889 citedByCount "0" @default.
• W3030998889 crossrefType "journal-article" @default.
• W3030998889 hasAuthorship W3030998889A5031682845 @default.
• W3030998889 hasAuthorship W3030998889A5048198282 @default.
• W3030998889 hasAuthorship W3030998889A5066588572 @default.
• W3030998889 hasAuthorship W3030998889A5068477955 @default.
• W3030998889 hasAuthorship W3030998889A5083455588 @default.
• W3030998889 hasConcept C109523444 @default.
• W3030998889 hasConcept C126322002 @default.
• W3030998889 hasConcept C2777055891 @default.
• W3030998889 hasConcept C2777649898 @default.
• W3030998889 hasConcept C2778165595 @default.
• W3030998889 hasConcept C2778716859 @default.
• W3030998889 hasConcept C2779914510 @default.
• W3030998889 hasConcept C42219234 @default.
• W3030998889 hasConcept C71924100 @default.
• W3030998889 hasConceptScore W3030998889C109523444 @default.
• W3030998889 hasConceptScore W3030998889C126322002 @default.
• W3030998889 hasConceptScore W3030998889C2777055891 @default.
• W3030998889 hasConceptScore W3030998889C2777649898 @default.
• W3030998889 hasConceptScore W3030998889C2778165595 @default.
• W3030998889 hasConceptScore W3030998889C2778716859 @default.
• W3030998889 hasConceptScore W3030998889C2779914510 @default.
• W3030998889 hasConceptScore W3030998889C42219234 @default.
• W3030998889 hasConceptScore W3030998889C71924100 @default.
• W3030998889 hasIssue "01" @default.
• W3030998889 hasLocation W30309988891 @default.
• W3030998889 hasOpenAccess W3030998889 @default.
• W3030998889 hasPrimaryLocation W30309988891 @default.
• W3030998889 hasRelatedWork W2028230740 @default.
• W3030998889 hasRelatedWork W2347505308 @default.
• W3030998889 hasRelatedWork W2359469333 @default.
• W3030998889 hasRelatedWork W2374396237 @default.
• W3030998889 hasRelatedWork W2374589221 @default.
• W3030998889 hasRelatedWork W2375588424 @default.
• W3030998889 hasRelatedWork W2381925344 @default.
• W3030998889 hasRelatedWork W2382759903 @default.
• W3030998889 hasRelatedWork W2384428162 @default.
• W3030998889 hasRelatedWork W2392256357 @default.
• W3030998889 hasRelatedWork W2410955019 @default.
• W3030998889 hasRelatedWork W2993969581 @default.
• W3030998889 hasRelatedWork W3029259002 @default.
• W3030998889 hasRelatedWork W3029976728 @default.
• W3030998889 hasRelatedWork W3030506522 @default.
• W3030998889 hasRelatedWork W3030892882 @default.
• W3030998889 hasRelatedWork W3030911916 @default.
• W3030998889 hasRelatedWork W3031768735 @default.
• W3030998889 hasRelatedWork W3032256176 @default.
• W3030998889 hasRelatedWork W3030731476 @default.
• W3030998889 hasVolume "18" @default.
• W3030998889 isParatext "false" @default.
• W3030998889 isRetracted "false" @default.
• W3030998889 magId "3030998889" @default.
• W3030998889 workType "article" @default.