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- W3031008067 abstract "Objective To evaluate effects of low-dose inhaled nitric oxide in earlier period of MAS on oxygenation function and inflammatory reaction.Methods Fifty-five newborns in the intensive care unit of Hebei Province Children Hospital from February 2005 to April 2007 were enrolled for study.All these MASpatients were mechanically ventilated and were divided randomly into Group A (mechanical ventilation+inhaled nitric oxide) and Group B(mechanical ventilation).OI,a/APO2 and PAP were monitored at 0 h,24 h,and 72 h after nitric oxide therapy.IL-8 and IL-10 were detected from venous blood and bronchoalveolar lavage fluid (BALF).A prospective study was carried on.Informed consent was obtained from parents before enrollment.The protocol and the informed consent forms were approved by the Institutional Review Board before patient enrollment.Results At 0 h,24 h and 72 h of Ino treatment,PAP were (76.20±12.96),(53.04±11.91),(41.76±11.51) mm Hg,respectively,OI were 13.10±3.00,10.99±2.37,8.37±0.27,whereas a/APO2 were 0.13±0.09,0.36±0.16,0.38±0.12 respectively.There were significant differences among OI,PAP and a/APO2 for different time points (P<0.05).Compared to group B,group A had shorter ventilation time [(77.38±13.97) h vs (104.27±10.53) h].Oxygen exposure time [(158.70±47.23) h vs (202.15±61.92) h] and hospital day[(13.24±3.62)d vs (16.81±3.43) d] were shorter in group A than those in group B.IL-8 was decreased in serum and BALF.IL-10 was increased with significant difference(P<0.05).Conclusion As a special therapy for MAS,NO inhalation cuts down pulmonary artery pressure,improves oxygenation,shortens ventilation time,and maybe regulates lung inflammatory reaction.Key words: Newborn infant ; Nitric Oxide ; Meconium aspiration syndrome ; Inflammation ; Cytokine ;" @default.
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- W3031008067 date "2008-06-20" @default.
- W3031008067 modified "2023-09-25" @default.
- W3031008067 title "Efficacy of inhaled nitric oxide on oxygenation function and inflammatory response in neonates with MAS" @default.
- W3031008067 doi "https://doi.org/10.3760/cma.j.issn.1673-4912.2008.03.010" @default.
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