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- W3031012218 startingPage "656" @default.
- W3031012218 abstract "帕金森病（Parkinson’s disease)是一种慢性进展的中枢神经系统变性疾病，临床上以静止性震颤、运动减少、肌张力障碍和步态异常为特点。罗替戈汀是当前治疗帕金森病的新型药物之一，为非麦角类多巴胺受体激动剂，可以结合多巴胺D1到D5受体以及五羟色胺1A受体，但是对D3受体的亲和力和激动作用最高［1］。罗替戈汀透皮贴剂是第一个非麦角类多巴胺受体激动剂贴剂［1］，每日给药1次就能够在24 h中提供稳定的血浆药物浓度。罗替戈汀透皮贴在欧洲和北美已经被批准用于帕金森病的治疗，在国内尚处于临床试验阶段。多个大型的多中心、双盲、随机、对照研究均显示，罗替戈汀对能明显改善帕金森病的运动症状，并且对帕金森病的非运动症状有一定改善作用［2］。" @default.
- W3031012218 created "2020-06-05" @default.
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- W3031012218 date "2014-09-08" @default.
- W3031012218 modified "2023-09-25" @default.
- W3031012218 title "罗替戈汀对帕金森病治疗作用研究进展" @default.
- W3031012218 doi "https://doi.org/10.3760/cma.j.issn.1006-7876.2014.09.013" @default.
- W3031012218 hasPublicationYear "2014" @default.
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