Matches in SemOpenAlex for { <https://semopenalex.org/work/W3031016893> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W3031016893 endingPage "1212" @default.
- W3031016893 startingPage "1210" @default.
- W3031016893 abstract "Objective To investigate the effect and mechanism of basiliximab preconditioning on renal ischemia/reperfusion injury.Methods Fifty-four C57BL/6 mice were divided into three groups randomly:sham-operated group (Sham group) ; ischemia/reperfusion group (IR group) [mice were injected with non-specific IgG (1 mg/kg) via tail vein 30 min before the operation] ; preconditioning with basiliximab group (Basiliximab group) [mice were injected with basiliximab (1 mg/kg) via tail vein 30 min before the operation].Then we occluded the renal pedicles on both sides for 45 min.Serum creatinine (Scr),blood urea nitrogen (BUN),fractional excretion of sodium (FENa),renal histology,CD4 + T lymphocytes,CD8 +T lymphocytes,interleukin (IL)-2,tumor necrosis factor (TNF)-α,and IL-6 in blood or the kidney were examined after reperfusion for 1,4,24 h.Results Compared with the Sham group,the levels of Scr [(174.33 ± 7.69),and (51.67 ± 6.56) μmol/L],BUN [(69.90 ± 1.68),and (23.97 ± 2.12) μ mol/L],FENa,the pathological injury scores,IL-2,TNF-α,and IL-6 were increased significantly in IR group and Basiliximab group after reperfusion for 24 h.CD4 + T lymphocytes were also increased in Basiliximab and IR groups after reperfusion for 4 h.All these variables were significantly decreased in Basiliximab group as compared with IR group.Conclusion Preconditioning with basiliximab alleviated renal ischemia/reperfusion injury probably by inhibiting CD4 +T lymphocytes proliferation and decreasing the expression of pro-inflammatory cytokines.Key words: Basiliximab ; T lymphocytes ; Renal ischemia ; Reperfusion injury" @default.
- W3031016893 created "2020-06-05" @default.
- W3031016893 creator A5029401372 @default.
- W3031016893 creator A5030285309 @default.
- W3031016893 creator A5063435450 @default.
- W3031016893 creator A5077232600 @default.
- W3031016893 creator A5087316150 @default.
- W3031016893 date "2014-06-08" @default.
- W3031016893 modified "2023-09-23" @default.
- W3031016893 title "Preconditioning with basiliximab protects renal ischemia/reperfusion injury by inhibiting T lymphocytes proliferation" @default.
- W3031016893 doi "https://doi.org/10.3760/cma.j.issn.1001-9030.2014.06.020" @default.
- W3031016893 hasPublicationYear "2014" @default.
- W3031016893 type Work @default.
- W3031016893 sameAs 3031016893 @default.
- W3031016893 citedByCount "0" @default.
- W3031016893 crossrefType "journal-article" @default.
- W3031016893 hasAuthorship W3031016893A5029401372 @default.
- W3031016893 hasAuthorship W3031016893A5030285309 @default.
- W3031016893 hasAuthorship W3031016893A5063435450 @default.
- W3031016893 hasAuthorship W3031016893A5077232600 @default.
- W3031016893 hasAuthorship W3031016893A5087316150 @default.
- W3031016893 hasConcept C126322002 @default.
- W3031016893 hasConcept C134018914 @default.
- W3031016893 hasConcept C17991360 @default.
- W3031016893 hasConcept C2778176769 @default.
- W3031016893 hasConcept C2780091579 @default.
- W3031016893 hasConcept C2780114680 @default.
- W3031016893 hasConcept C2780303639 @default.
- W3031016893 hasConcept C2780306776 @default.
- W3031016893 hasConcept C2780343553 @default.
- W3031016893 hasConcept C2780721119 @default.
- W3031016893 hasConcept C2781307858 @default.
- W3031016893 hasConcept C541997718 @default.
- W3031016893 hasConcept C71924100 @default.
- W3031016893 hasConcept C98274493 @default.
- W3031016893 hasConceptScore W3031016893C126322002 @default.
- W3031016893 hasConceptScore W3031016893C134018914 @default.
- W3031016893 hasConceptScore W3031016893C17991360 @default.
- W3031016893 hasConceptScore W3031016893C2778176769 @default.
- W3031016893 hasConceptScore W3031016893C2780091579 @default.
- W3031016893 hasConceptScore W3031016893C2780114680 @default.
- W3031016893 hasConceptScore W3031016893C2780303639 @default.
- W3031016893 hasConceptScore W3031016893C2780306776 @default.
- W3031016893 hasConceptScore W3031016893C2780343553 @default.
- W3031016893 hasConceptScore W3031016893C2780721119 @default.
- W3031016893 hasConceptScore W3031016893C2781307858 @default.
- W3031016893 hasConceptScore W3031016893C541997718 @default.
- W3031016893 hasConceptScore W3031016893C71924100 @default.
- W3031016893 hasConceptScore W3031016893C98274493 @default.
- W3031016893 hasIssue "06" @default.
- W3031016893 hasLocation W30310168931 @default.
- W3031016893 hasOpenAccess W3031016893 @default.
- W3031016893 hasPrimaryLocation W30310168931 @default.
- W3031016893 hasRelatedWork W1966624249 @default.
- W3031016893 hasRelatedWork W1982482424 @default.
- W3031016893 hasRelatedWork W2350198497 @default.
- W3031016893 hasRelatedWork W2356776554 @default.
- W3031016893 hasRelatedWork W2358405068 @default.
- W3031016893 hasRelatedWork W2362993415 @default.
- W3031016893 hasRelatedWork W2375125288 @default.
- W3031016893 hasRelatedWork W2383918258 @default.
- W3031016893 hasRelatedWork W2588152332 @default.
- W3031016893 hasRelatedWork W2588894693 @default.
- W3031016893 hasRelatedWork W2971532425 @default.
- W3031016893 hasRelatedWork W2973181845 @default.
- W3031016893 hasRelatedWork W3029907169 @default.
- W3031016893 hasRelatedWork W3030313746 @default.
- W3031016893 hasRelatedWork W3031039740 @default.
- W3031016893 hasRelatedWork W3032490665 @default.
- W3031016893 hasRelatedWork W3032515621 @default.
- W3031016893 hasRelatedWork W3032516461 @default.
- W3031016893 hasRelatedWork W3032546023 @default.
- W3031016893 hasRelatedWork W3032825489 @default.
- W3031016893 hasVolume "31" @default.
- W3031016893 isParatext "false" @default.
- W3031016893 isRetracted "false" @default.
- W3031016893 magId "3031016893" @default.
- W3031016893 workType "article" @default.