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- W3031036304 abstract "Objective To evaluate the effects of chronic exposure to sub-anesthetic concentrations of sevoflurane on memory function and homeostasis of mice.Methods Thirty-six healthy male Kunming mice,aged 40 days,weighing 25-30 g,were randomly assigned into 3 groups (n =12 each):control group (group C),0.1％ sevoflurane group (group L) and 0.5 ％ sevoflurane group (group H).The mice inhaled 0.1％ (group L) or 0.5％ sevoflurane (group H) between 18:00-6:00 (the next day) every night for 30 days.Water maze test was performed at 27-30 days of inhalation.Blood samples were collected from the left ventricle for blood gas analysis and for determination of blood electrolytes.Results There was no significant difference in swimming time in Water maze test,number of errors and blood gas analysis and blood electrolytes.Conclusion Chronic exposure to subanesthetic concentrations of sevoflurane has no significant effects on memory function and homeostasis of mice.Key words: Anesthetics, inhalation ; Occupational exposure ; Memory ; Homeostasis" @default.
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- W3031036304 date "2014-04-20" @default.
- W3031036304 modified "2023-09-24" @default.
- W3031036304 title "Effects of chronic exposure to sub-anesthetic concentrations of sevoflurane on memory function and homeostasis of mice" @default.
- W3031036304 doi "https://doi.org/10.3760/cma.j.issn.0254-1416.2014.04.021" @default.
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