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- W3031038817 abstract "ObjectiveTo investigate the clinical characteristics of plasma cell malignancies with t(11;14) and the effect of t(11;14) on prognosis.MethodsA cohort of 380 newly diagnosed patients with plasma cell malignancies were analyzed, including 146 females and 234 males. There were 370 cases of newly diagnosed multiple myeloma (NDMM), as well as 10 cases of primary plasma cell leukemia (PCL). The relationship between the categorical variables was evaluated by using the bilateral Fisher exact probability test, with 95% confidence interval.ResultsOf 370 NDMM cases, t(11;14) was detected in 101 cases (27.3%). Of 10 PCL cases, 8 cases displayed t(11;14). The detection rate of t(11;14) was significantly higher in IgD, IgM and non-secreting MM [50.9% (27/53)] than that in IgA MM [21.6% (16/78)] and IgG [28.4% (52/183)] (both P = 0.002). The rate of CD56+ in t(11;14) positive group was lower than that in t(11;14) negative group [51.6% (48/93) vs. 72.0% (167/232), P = 0.001], and the rate of CD117+ was also significantly decreased [23.7% (22/93) vs. 37.7% (87/231), P = 0.019]. There were 86 cases of non-t(11;14) IgH rearrangement in 269 cases of NDMM without t(11;14), which mainly were t(4;14) or t(14;16). The detection rate of high risk MM was only 11.9% (12/101) in t(11;14) positive group, while that rate was 27.5% (74/269) in t(11;14) negative group, the difference was statistically significant (P = 0.001).ConclusionMM with t(11;14) displays distinct biological, clinical and laboratory features, it is a heterogeneous disease.Key words: Multiple myeloma; Translocation, genetic; Antigens, CD56; Antigens, CD117" @default.
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- W3031038817 date "2017-10-25" @default.
- W3031038817 modified "2023-09-23" @default.
- W3031038817 title "Plasma cell malignancies with t(11;14): clinical analysis of 380 cases" @default.
- W3031038817 doi "https://doi.org/10.3760/cma.j.issn.1009-9921.2017.10.004" @default.
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