FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3031051657> ?p ?o ?g. }

• W3031051657 endingPage "171" @default.
• W3031051657 startingPage "166" @default.
• W3031051657 abstract "ObjectiveTo investigate the association between polymorphism of MS4A2 gene rs569108 locus and susceptibility, severity of wheezing illnesses in children under 6 years old.MethodsFrom January 2014 to December 2016, a total of 236 children under 6 years old with wheezing illnesses in Guangdong Women and Children Hospital were enrolled as case group. And 121 healthy children with the same age who received health examination in the same hospital during the same period were selected as control group. Oral epithelial cell samples were collected from the subjects in two groups, and DNA was abstracted from the buccal mucosa epithelia. Genotypings of MS4A2 gene rs569108 locus polymorphism were performed by real-time-fluorescence quantitation PCR. Genetic Hardy-Weinberg equilibrium, distribution of alleles A and B and genotypes AA, AG and GG of MS4A2 gene rs569108 locus polymorphism between two groups, distribution of genotypes AA, AG and GG of children with different severity degrees of wheezing illnesses in case group were compared by chi-square test. The guardians of all subjects were told and signed the informed consent agreement when their children were included as research subjects. There were no significant differences between two groups in the aspects of gender ratio and age, etc. (P>0.05).Results①The distributions of genotypes AA, AG and GG of MS4A2 gene rs569108 locus polymorphism of case group and control group were both in line with Hardy-Weinberg equilibrium (P>0.05), indicating that the samples of both two groups were representative. ②There were no significant differences between two groups in the frequencies of genotypes AA, AG, GG or alleles A and G of MS4A2 gene rs569108 locus polymorphism (P>0.05). ③In case group, the frequencies of genotypes AA, AG, GG of MS4A2 gene rs569108 locus polymorphism in children with mild, moderate, severe wheezing illnesses were 75.5% (108/143), 23.8% (34/143) and 0.7% (1/143), respectively, 67.7% (42/62), 30.1% (18/62) and 3.2% (2/62), respectively, and 58.1% (18/31), 32.2% (10/31) and 9.7% (3/31), respectively. There was significant difference among the three severity degrees of wheezing illnesses in the frequencies of genotypes AA, AG, GG of MS4A2 gene rs569108 locus polymorphism (χ2=9.186, P=0.039). And there was significant difference between the children with mild or severe wheezing illnesses in the frequencies genotypes AA, AG, and GG by multiple comparisons (χ2=8.506, P=0.011).ConclusionsThere is no correlation between polymorphism of MS4A2 gene rs569108 locus and the susceptibility of wheezing illnesses in children under 6 years old. But there is correlation between the severity of wheezing illnesses in children under 6 years old and the polymorphism of MS4A2 gene rs569108 locus. It shows that wheezing children under 6 years old with GG genotype are more susceptible to get more severe degree when wheezing attacks.Key words: Polymorphism, single nucleotide; MS4A2 gene; rs569108 locus; Gasping; Asthma; Child" @default.
• W3031051657 created "2020-06-05" @default.
• W3031051657 creator A5002905754 @default.
• W3031051657 creator A5049840855 @default.
• W3031051657 creator A5069508153 @default.
• W3031051657 creator A5084366911 @default.
• W3031051657 date "2018-04-01" @default.
• W3031051657 modified "2023-09-28" @default.
• W3031051657 title "Relationship between polymorphism of MS4A2 gene rs569108 locus and wheezing illnesses in children under 6 years old" @default.
• W3031051657 doi "https://doi.org/10.3877/cma.j.issn.1673-5250.2018.02.007" @default.
• W3031051657 hasPublicationYear "2018" @default.
• W3031051657 type Work @default.
• W3031051657 sameAs 3031051657 @default.
• W3031051657 citedByCount "0" @default.
• W3031051657 crossrefType "journal-article" @default.
• W3031051657 hasAuthorship W3031051657A5002905754 @default.
• W3031051657 hasAuthorship W3031051657A5049840855 @default.
• W3031051657 hasAuthorship W3031051657A5069508153 @default.
• W3031051657 hasAuthorship W3031051657A5084366911 @default.
• W3031051657 hasConcept C104317684 @default.
• W3031051657 hasConcept C126322002 @default.
• W3031051657 hasConcept C135763542 @default.
• W3031051657 hasConcept C167871757 @default.
• W3031051657 hasConcept C180754005 @default.
• W3031051657 hasConcept C187212893 @default.
• W3031051657 hasConcept C54355233 @default.
• W3031051657 hasConcept C71924100 @default.
• W3031051657 hasConcept C84597430 @default.
• W3031051657 hasConcept C86803240 @default.
• W3031051657 hasConcept C90924648 @default.
• W3031051657 hasConceptScore W3031051657C104317684 @default.
• W3031051657 hasConceptScore W3031051657C126322002 @default.
• W3031051657 hasConceptScore W3031051657C135763542 @default.
• W3031051657 hasConceptScore W3031051657C167871757 @default.
• W3031051657 hasConceptScore W3031051657C180754005 @default.
• W3031051657 hasConceptScore W3031051657C187212893 @default.
• W3031051657 hasConceptScore W3031051657C54355233 @default.
• W3031051657 hasConceptScore W3031051657C71924100 @default.
• W3031051657 hasConceptScore W3031051657C84597430 @default.
• W3031051657 hasConceptScore W3031051657C86803240 @default.
• W3031051657 hasConceptScore W3031051657C90924648 @default.
• W3031051657 hasIssue "02" @default.
• W3031051657 hasLocation W30310516571 @default.
• W3031051657 hasOpenAccess W3031051657 @default.
• W3031051657 hasPrimaryLocation W30310516571 @default.
• W3031051657 hasRelatedWork W2351148858 @default.
• W3031051657 hasRelatedWork W2366881140 @default.
• W3031051657 hasRelatedWork W2372917770 @default.
• W3031051657 hasRelatedWork W2384571814 @default.
• W3031051657 hasRelatedWork W2395487954 @default.
• W3031051657 hasRelatedWork W2401298661 @default.
• W3031051657 hasRelatedWork W2406348010 @default.
• W3031051657 hasRelatedWork W2416051493 @default.
• W3031051657 hasRelatedWork W2418959685 @default.
• W3031051657 hasRelatedWork W2468403960 @default.
• W3031051657 hasRelatedWork W2549795977 @default.
• W3031051657 hasRelatedWork W2791837915 @default.
• W3031051657 hasRelatedWork W2794249900 @default.
• W3031051657 hasRelatedWork W2888519601 @default.
• W3031051657 hasRelatedWork W2904775727 @default.
• W3031051657 hasRelatedWork W3024419056 @default.
• W3031051657 hasRelatedWork W3026705497 @default.
• W3031051657 hasRelatedWork W3032589173 @default.
• W3031051657 hasRelatedWork W3032739536 @default.
• W3031051657 hasRelatedWork W3038861155 @default.
• W3031051657 hasVolume "14" @default.
• W3031051657 isParatext "false" @default.
• W3031051657 isRetracted "false" @default.
• W3031051657 magId "3031051657" @default.
• W3031051657 workType "article" @default.