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- W3031056026 abstract "目的:探讨卡维地洛对心绞痛患者纤溶性、内皮素、一氧化氮、降钙素基因相关肽的影响.方法:48例初发劳累性心绞痛患者,随机分为常规治疗组、卡维地洛治疗组,26例健康体检者作为正常对照组,观察用药前后血t-PA、PAI活性,ET、NO、CGRP浓度的变化.结果:心绞痛患者t-PA活性、CGRP和NO浓度明显低于正常对照组(P＜0.01),而PAI活性、ET浓度明显高于正常对照组(P＜0.01),常规治疗组与卡维地洛治疗组治疗后t-PA活性显著升高(P＜0.01),PAI活性显著下降(P＜0.01),治疗后t-PA活性的变化两组间无显著性差异(P＞0.05),PAI活性的变化两组间对比有极显著性差异(P＜0.01).两组治疗后,血NO、CGRP浓度均较治疗前显著升高(P＜0.01),卡维地洛组与常规治疗组组间对比有极显著性差异(P＜0.01),常规治疗组治疗前后血ET浓度无显著性变化(P＞0.01),而卡维地洛治疗组血ET浓度显著下降(P＜0.01).结论:心绞痛患者纤溶活性和内皮功能异常,卡维地洛可改善心绞痛患者纤溶活性和内皮功能." @default.
- W3031056026 created "2020-06-05" @default.
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- W3031056026 date "2003-09-10" @default.
- W3031056026 modified "2023-09-25" @default.
- W3031056026 title "卡维地洛对心绞痛患者纤溶活性和内皮血管活性物质的影响" @default.
- W3031056026 doi "https://doi.org/10.3760/cma.j.issn.1674-4756.2003.17.045" @default.
- W3031056026 hasPublicationYear "2003" @default.
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