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- W3031057378 abstract "ObjectiveTo test whether nicotine induces the secretion of transforming growth factor-β1 (TGF-β1)and fibroblast growth factor 2 (FGF-2) in HBECs in vitro via the high mobility group protein B1 (HMGB1)/receptor for advanced glycation end products (RAGE) signaling pathway.MethodsCultured HBECs were exposed to nicotine (6×10-6 mol/L) for 24 h. The secretion of HMGB1, TGF-β1 and FGF-2 was assessed by ELISA, the expression of RAGE was assessed by Western blotting.HBECs were either transfected with a small interfering RNA (siRNA) targeting HMGB1 for 48 h or incubated with anti-RAGE antibodies for 1 h and subsequently stimulated with nicotine for 24 h, then the secretion of HMGB1, TGF-β1 and FGF-2 was assessed by ELISA, the expression of RAGE was assessed by Western blotting.ResultsWe showed that cells exposed to nicotine for 24 h exhibited significantly increased HMGB1, TGF-β1 and FGF-2 secretion and RAGE expression.The HMGB1 siRNA prevented these effects.Furthermore, anti-RAGE antibodies significantly decreased the secretion of TGF-β1 and FGF-2 from HBECs.ConclusionsThese results suggest that nicotine induces the secretion of TGF-β1 and FGF-2 in HBECs via the HMGB1/RAGE signaling pathway.Key words: Nicotine; Transforming growth factor beta1; Fibroblast growth factor 2; Human bronchial epithelial cells; High mobility group protein B1/Receptor for advanced glycation end products" @default.
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- W3031057378 date "2020-03-05" @default.
- W3031057378 modified "2023-09-28" @default.
- W3031057378 title "Nicotine induces the secretion of TGF-β1 and FGF-2 via HMGB1/RAGE in human airway epithelial cells" @default.
- W3031057378 doi "https://doi.org/10.3760/cma.j.issn.1673-436x.2020.05.008" @default.
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