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- W3031060067 abstract "目的探讨含有血管生成抑制因子、肿瘤细胞抑制因子和酸性粘多糖的鲨鱼软骨提取物对小鼠接种肿瘤生长的抑制效应.方法用东海鲸鲨软骨制备得到鲨鱼软骨提取物.采用C57BL/6小鼠,小鼠Lewis肺癌腋皮下接种模型,接种第2天腹腔注射给药,连续给药8d,观察抑瘤率;小鼠Lewis肺癌足趾皮下接种模型,接种第2天腹腔注射给药,连续给药10 d,观察抑瘤率.结果腋皮下接种模型,高剂量组125mg/kg的抑瘤率为46.61%,中剂量组50 mg/kg的抑瘤率为37.56%,低剂量组20mg/kg的抑瘤率为26.24%;足趾皮下接种模型,超高剂量组250 mg/kg抑瘤率为57.68%,高剂量组125mg/kg为54.44%,中剂量组50 mg/kg为42.64%,低剂量组20 mg/kg为33.87%.结论鲨鱼软骨提取物具有明显抑瘤作用." @default.
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- W3031060067 date "2002-01-28" @default.
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- W3031060067 title "Inhibitory effect of shark cartilage extract on the growth of Lewis lung carcinoma transplanted in mice" @default.
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