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• W3031065892 abstract "Objective To investigate the protective effect of rhizoma paridis total saponins (重楼总皂苷) and its mechanism on septic rats. Methods Septic model was reproduced by cecal ligation and puncture (CLP) in Wistar rats. Rhizoma paridis total saponins was administered to observe its protective effects on septic rats. Blood was collected to determine serum tumor necrosis factor-a (TNF-a) and interleukin-1β (IL-1β) levels at 2, 6, 12, 24 and 48 hours after operation by means of enzyme-linked irnmunosorbent assay (ELISA). The pathological changes of lung tissue were observed with light microscope at 72 hours after operation. The peritoneal macrophages (PMΦ) in rats were isolated and the release of TNF-a and IL-1β in PMΦ after exposure to lipopolysaecharide (LPS, 100 μg/L) were measured by ELISA. Results Mortality in the rhizoma paridis total saponins group was significantly lower than the CLP group (50.0% vs. 85.0%,P<0.05). The levels of TNF-a and IL-1β in serum were significantly lower than those of the CLP group at the same time (P<0.05 or P<0.01). The degree of inflammatory injury to the lung was much milder than that in the CLP group. In the in vitro experiment, it was shown that rhizoma paridis total saponins in concentrations of 5, 10, 20 and 40 mg/L could inhibit remarkably the release of TNF-a and IL-1β from LPS-stimulated PMΦ of rats (all P<0.01). The differences in TNF-a levels among the groups showed no statistically significant difference (all P0.05). The level of IL-1β in 5 mg/L group was significantly higher than that of the 10 mg/L group (P<0.05), but showed no difference with those of 20 mg/L and 40 mg/L groups (both P0.05). Conclusion Rhizoma paridis total saponins can protect the CLP rats by inhibiting the activation of rat PMΦ to release cytokines and ameliorating acute lung injury.Key words: rhizoma paridis total saponins ;  sepsis ;  macrophage ;  tumor necrosis factor-a ;  interleukin-1β ;  liooootvsaccharide ;" @default.
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• W3031065892 date "2008-09-10" @default.
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• W3031065892 title "Protective effects of rhizoma paridis total saponins (重楼总皂苷) on septic rats" @default.
• W3031065892 doi "https://doi.org/10.3321/j.issn:1003-0603.2008.09.016" @default.
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