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- W3031082920 abstract "ObjectiveTo investigate the effect of vascular endothelial growth factor (VEGF) inhibitor on lung function in mice after unilateral pneumonectomy.Methods45 male C57BL/6 mice undergoing left pneumonectomy were divided into 0 μ g/kg (control group), 5.0 μ g/kg group, 20 μ g/kg group, 60 μ g/kg group and 180 μ g/kg group according to the injection dose of VEGF receptor 1. The daily dosage of each group were 0, 5.0, 20, 60, 180 μg/kg, After 4 days of feeding, the lung volume, lung volume and lung compliance were compared, and the expression of VEGF was further compared, and the expression of hypoxia-inducible factor (HIF) and its related genes were analyzed.ResultsThe VEGF receptor 1 pharmacokinetic model was fitted to a two-compartment model: C=A1 e(-Ke t) + A2 e(-Kα t) + A3 e(-Kβ t). The half-life of VEGF receptor 1 [t1/2 (K)] is 25.997 h; Observed 4 days after surgery, the lung volume value of the 20 μg/kg group was the largest [(64.8±5.1) μl/g]. Compared with the control group (0 μg/kg), the right lung volume of the mice in the 5 μg/kg groups was significantly lower (P<0.05), while the right lung volume in the 60 μg/kg group and the 80 μg/kg group did not obvious change. The right lung volume, total volume and compliance of the mice in the 20 μg/kg group were significantly higher than those in the control group (t=6.568, 11.436, 9.391, P<0.05). Compared with the control group, the expression of VEGFr2 and VEGF mRNA in the 20 μg/kg VEGFr1 group was significantly increased (t=7.425, 9.391, P<0.05). The VEGF content in the lung and plasma of 20 μg/kg VEGFr1 mice was significantly higher than that of the control group (t=23.764, 6.972, P<0.05); (6) The expression of HIF-2α and the expression of HIF-related genes PH, VHL, CXCR4, HK, PDK and PDGFα in the 20 μg/kg group were significantly higher than those in the control group (t=6.486, 12.283, 12.283, 5.134, 12.671, 8.870, P<0.05).ConclusionVEGF inhibitor can effectively promote the growth of right lung after left lung resection in mice by stimulating HIF at a concentration of 20μg/kg.Key words: Vascular endothelial growth factor; Inhibitor; Mouse; Unilateral pneumonectomy; Lung function" @default.
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- W3031082920 date "2019-11-08" @default.
- W3031082920 modified "2023-09-25" @default.
- W3031082920 title "Effects of vascular endothelial growth factor inhibitor on lung function in mice after unilateral pneumonectomy" @default.
- W3031082920 doi "https://doi.org/10.3760/cma.j.issn.1001-9030.2019.11.042" @default.
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