Matches in SemOpenAlex for { <https://semopenalex.org/work/W3031099552> ?p ?o ?g. }
- W3031099552 endingPage "1389" @default.
- W3031099552 startingPage "1389" @default.
- W3031099552 abstract "The role of astrocytes on glutamate release and differentiation of glioma stem cells (GSCs) remains unknown. We investigated glutamate release, proliferation, and differentiation of GSCs after indirect incubation with astrocytes in vitro, including morphology change, GFAP expression, glutamine synthetase, and EAAT1 expression. The role of formyl peptide receptor (FPR) agonist and antagonist on interaction between astrocytes and GSCs in co-culture model was analyzed. We found: (1) After incubation of astrocytes and GSCs, differentiated GSCs present the morphology of astrocytes and express GFAP. (2) GSCs release high concentration of glutamate, as well as tumor cells. However, differentiated GSCs possess the ability of glutamate uptake. (3) Proliferation ability of differentiated GSCs is lower than tumor cells. (4) Glutamine synthetase is predominantly expressed in the nucleus of tumor cells, while in the cytoplasm of differentiated GSCs. (5) Differentiation of GSCs could be triggered by FPR agonist, while astrocyte-induced differentiation of GSCs could be blocked by FPR antagonist. These results indicate astrocytes promote astrocytic differentiation and glutamate uptake of GSCs via FPR." @default.
- W3031099552 created "2020-06-05" @default.
- W3031099552 creator A5023409517 @default.
- W3031099552 creator A5042125237 @default.
- W3031099552 creator A5073478417 @default.
- W3031099552 creator A5085144454 @default.
- W3031099552 date "2020-05-30" @default.
- W3031099552 modified "2023-09-24" @default.
- W3031099552 title "RETRACTED ARTICLE: Astrocytes Regulate Differentiation and Glutamate Uptake of Glioma Stem Cells via Formyl Peptide Receptor" @default.
- W3031099552 cites W1519055819 @default.
- W3031099552 cites W1559213768 @default.
- W3031099552 cites W1807507622 @default.
- W3031099552 cites W1808840521 @default.
- W3031099552 cites W1968876099 @default.
- W3031099552 cites W1976824217 @default.
- W3031099552 cites W1982752408 @default.
- W3031099552 cites W1983661525 @default.
- W3031099552 cites W1987080089 @default.
- W3031099552 cites W1988854646 @default.
- W3031099552 cites W1992521533 @default.
- W3031099552 cites W1995311865 @default.
- W3031099552 cites W1995591875 @default.
- W3031099552 cites W1997075641 @default.
- W3031099552 cites W2013767913 @default.
- W3031099552 cites W2018283924 @default.
- W3031099552 cites W2018640258 @default.
- W3031099552 cites W2029624481 @default.
- W3031099552 cites W2043985651 @default.
- W3031099552 cites W2053146787 @default.
- W3031099552 cites W2059311738 @default.
- W3031099552 cites W2069897030 @default.
- W3031099552 cites W2073678040 @default.
- W3031099552 cites W2078510083 @default.
- W3031099552 cites W2082051295 @default.
- W3031099552 cites W2082805232 @default.
- W3031099552 cites W2093000696 @default.
- W3031099552 cites W2110631752 @default.
- W3031099552 cites W2127459925 @default.
- W3031099552 cites W2127617517 @default.
- W3031099552 cites W2128853794 @default.
- W3031099552 cites W2152462284 @default.
- W3031099552 cites W2152562611 @default.
- W3031099552 cites W2171680453 @default.
- W3031099552 cites W2174361280 @default.
- W3031099552 cites W2388997203 @default.
- W3031099552 cites W2498509180 @default.
- W3031099552 cites W2771593474 @default.
- W3031099552 cites W2773990262 @default.
- W3031099552 cites W2795802217 @default.
- W3031099552 cites W2900657225 @default.
- W3031099552 cites W2953714808 @default.
- W3031099552 cites W4210979710 @default.
- W3031099552 cites W4233707563 @default.
- W3031099552 cites W983771422 @default.
- W3031099552 doi "https://doi.org/10.1007/s10571-020-00886-3" @default.
- W3031099552 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32474726" @default.
- W3031099552 hasPublicationYear "2020" @default.
- W3031099552 type Work @default.
- W3031099552 sameAs 3031099552 @default.
- W3031099552 citedByCount "0" @default.
- W3031099552 crossrefType "journal-article" @default.
- W3031099552 hasAuthorship W3031099552A5023409517 @default.
- W3031099552 hasAuthorship W3031099552A5042125237 @default.
- W3031099552 hasAuthorship W3031099552A5073478417 @default.
- W3031099552 hasAuthorship W3031099552A5085144454 @default.
- W3031099552 hasBestOaLocation W30310995521 @default.
- W3031099552 hasConcept C104317684 @default.
- W3031099552 hasConcept C134018914 @default.
- W3031099552 hasConcept C148738053 @default.
- W3031099552 hasConcept C153911025 @default.
- W3031099552 hasConcept C170493617 @default.
- W3031099552 hasConcept C2777542381 @default.
- W3031099552 hasConcept C2778227246 @default.
- W3031099552 hasConcept C2778938600 @default.
- W3031099552 hasConcept C2779289688 @default.
- W3031099552 hasConcept C2779349466 @default.
- W3031099552 hasConcept C28328180 @default.
- W3031099552 hasConcept C502942594 @default.
- W3031099552 hasConcept C515207424 @default.
- W3031099552 hasConcept C529278444 @default.
- W3031099552 hasConcept C55493867 @default.
- W3031099552 hasConcept C61174792 @default.
- W3031099552 hasConcept C86803240 @default.
- W3031099552 hasConcept C95444343 @default.
- W3031099552 hasConceptScore W3031099552C104317684 @default.
- W3031099552 hasConceptScore W3031099552C134018914 @default.
- W3031099552 hasConceptScore W3031099552C148738053 @default.
- W3031099552 hasConceptScore W3031099552C153911025 @default.
- W3031099552 hasConceptScore W3031099552C170493617 @default.
- W3031099552 hasConceptScore W3031099552C2777542381 @default.
- W3031099552 hasConceptScore W3031099552C2778227246 @default.
- W3031099552 hasConceptScore W3031099552C2778938600 @default.
- W3031099552 hasConceptScore W3031099552C2779289688 @default.
- W3031099552 hasConceptScore W3031099552C2779349466 @default.
- W3031099552 hasConceptScore W3031099552C28328180 @default.
- W3031099552 hasConceptScore W3031099552C502942594 @default.
- W3031099552 hasConceptScore W3031099552C515207424 @default.
- W3031099552 hasConceptScore W3031099552C529278444 @default.