Matches in SemOpenAlex for { <https://semopenalex.org/work/W3031117437> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W3031117437 endingPage "10" @default.
- W3031117437 startingPage "6" @default.
- W3031117437 abstract "Objective To investigate whether diazoxide preconditioning protects cerebrum against i(s)chemia reperfusion injury via mitochondrial calcium uniporter(MCU)or not.Methods The ischemia reperfusion model was performed by thread occlusion of middle cerebral artery for 2 h,and then 24 h reperfusion.Fifty-two rats were randomly divided into four groups:group A (sham-operated group),group B(ischemia/reperfusion group),group C(diazoxide group),group D(diazozide-spermine group).After 24 h reperfusion,neuropsychological score,the mitochondrial calcium content([Ca2+]m),,the activity of superoxide dismutase (SOD)and glutathione peroxidase(GSH-Px),the content of malondialdehyde(MDA)and nitric oxide(NO)in ischemic hemisphere were observed in above groups respectively.Results Compared with group B,diazoxide preconditioning in group C improved neuropsychological score(13.1 ±0.8,P＜0.01),improved the activity of SOD(143 ±-18)U/mgprot and GSH-Px(84 ±8)U/mgprot(P＜0.05),and decreased the content of MDA(0.799 ±0.092)nmol/mgprot and NO(0.216±0.138)nmol/mgprot(P＜0.05)and[Ca2+]m (293±7)nmol/mgprot(P＜0.01).Spermine in group D attenuated the beneficial effects of diazoxide preconditioning in group C.Compared with group C,spermine attenuated neuropsychological score(8.0±0.7,P＜0.01)and the activity of SOD(128±7)U/mgprot and GSH-Px(73 ±6)U/mgprot(P＜0.05),and improved[Ca2+]m(322±10)nmol/mgprot(P＜0.01)and the content of MDA (0.955±0.141)nmol/mgprot and NO(0.575±0.292)nmol/mgprot(P＜0.05).Conclusions The effects of diazoxide preconditioning against cerebral ischemia reperfusion injury by attenuating[Ca2+]m and peroxidation injury in rats may involve in the suppression of MCU during reperfusion.Key words: Diazoxide; Spermine; Mitochondria; Brain ischemia; Reperfusion" @default.
- W3031117437 created "2020-06-05" @default.
- W3031117437 creator A5012278873 @default.
- W3031117437 creator A5039843021 @default.
- W3031117437 creator A5057514007 @default.
- W3031117437 creator A5058371096 @default.
- W3031117437 creator A5083486827 @default.
- W3031117437 creator A5086017278 @default.
- W3031117437 date "2012-01-15" @default.
- W3031117437 modified "2023-09-22" @default.
- W3031117437 title "Diazoxide preconditioning protects cerebrum against ischemia/reperfusion injury via mitochondrial calcium uniporter" @default.
- W3031117437 doi "https://doi.org/10.3760/cma.j.issn.1673-4378.2012.01.002" @default.
- W3031117437 hasPublicationYear "2012" @default.
- W3031117437 type Work @default.
- W3031117437 sameAs 3031117437 @default.
- W3031117437 citedByCount "0" @default.
- W3031117437 crossrefType "journal-article" @default.
- W3031117437 hasAuthorship W3031117437A5012278873 @default.
- W3031117437 hasAuthorship W3031117437A5039843021 @default.
- W3031117437 hasAuthorship W3031117437A5057514007 @default.
- W3031117437 hasAuthorship W3031117437A5058371096 @default.
- W3031117437 hasAuthorship W3031117437A5083486827 @default.
- W3031117437 hasAuthorship W3031117437A5086017278 @default.
- W3031117437 hasConcept C126322002 @default.
- W3031117437 hasConcept C134018914 @default.
- W3031117437 hasConcept C181199279 @default.
- W3031117437 hasConcept C185592680 @default.
- W3031117437 hasConcept C2775838275 @default.
- W3031117437 hasConcept C2776109719 @default.
- W3031117437 hasConcept C2776151105 @default.
- W3031117437 hasConcept C2778401633 @default.
- W3031117437 hasConcept C2778760513 @default.
- W3031117437 hasConcept C2779306644 @default.
- W3031117437 hasConcept C2779872217 @default.
- W3031117437 hasConcept C42219234 @default.
- W3031117437 hasConcept C519063684 @default.
- W3031117437 hasConcept C519581460 @default.
- W3031117437 hasConcept C541997718 @default.
- W3031117437 hasConcept C55493867 @default.
- W3031117437 hasConcept C71924100 @default.
- W3031117437 hasConcept C98274493 @default.
- W3031117437 hasConceptScore W3031117437C126322002 @default.
- W3031117437 hasConceptScore W3031117437C134018914 @default.
- W3031117437 hasConceptScore W3031117437C181199279 @default.
- W3031117437 hasConceptScore W3031117437C185592680 @default.
- W3031117437 hasConceptScore W3031117437C2775838275 @default.
- W3031117437 hasConceptScore W3031117437C2776109719 @default.
- W3031117437 hasConceptScore W3031117437C2776151105 @default.
- W3031117437 hasConceptScore W3031117437C2778401633 @default.
- W3031117437 hasConceptScore W3031117437C2778760513 @default.
- W3031117437 hasConceptScore W3031117437C2779306644 @default.
- W3031117437 hasConceptScore W3031117437C2779872217 @default.
- W3031117437 hasConceptScore W3031117437C42219234 @default.
- W3031117437 hasConceptScore W3031117437C519063684 @default.
- W3031117437 hasConceptScore W3031117437C519581460 @default.
- W3031117437 hasConceptScore W3031117437C541997718 @default.
- W3031117437 hasConceptScore W3031117437C55493867 @default.
- W3031117437 hasConceptScore W3031117437C71924100 @default.
- W3031117437 hasConceptScore W3031117437C98274493 @default.
- W3031117437 hasIssue "01" @default.
- W3031117437 hasLocation W30311174371 @default.
- W3031117437 hasOpenAccess W3031117437 @default.
- W3031117437 hasPrimaryLocation W30311174371 @default.
- W3031117437 hasRelatedWork W1983125335 @default.
- W3031117437 hasRelatedWork W2026348918 @default.
- W3031117437 hasRelatedWork W2039520805 @default.
- W3031117437 hasRelatedWork W2085778837 @default.
- W3031117437 hasRelatedWork W2353283353 @default.
- W3031117437 hasRelatedWork W2354170681 @default.
- W3031117437 hasRelatedWork W2360777352 @default.
- W3031117437 hasRelatedWork W2361795738 @default.
- W3031117437 hasRelatedWork W2367887591 @default.
- W3031117437 hasRelatedWork W2370127019 @default.
- W3031117437 hasRelatedWork W2372934171 @default.
- W3031117437 hasRelatedWork W2374516692 @default.
- W3031117437 hasRelatedWork W2379652562 @default.
- W3031117437 hasRelatedWork W2379698561 @default.
- W3031117437 hasRelatedWork W2380643348 @default.
- W3031117437 hasRelatedWork W2381940704 @default.
- W3031117437 hasRelatedWork W2386808562 @default.
- W3031117437 hasRelatedWork W2392915388 @default.
- W3031117437 hasRelatedWork W3028763528 @default.
- W3031117437 hasRelatedWork W3032218250 @default.
- W3031117437 hasVolume "33" @default.
- W3031117437 isParatext "false" @default.
- W3031117437 isRetracted "false" @default.
- W3031117437 magId "3031117437" @default.
- W3031117437 workType "article" @default.