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- W3031122912 abstract "ObjectiveTo analyze the survival rate and adverse effect of therapy of childhood supratentorial primitive neuroectoderma (sPNET) patients in order to investigate a suitable therapy.MethodsBetween December 2012 and December 2014, 18 children, aged from 0.6 to 13.6 years old, were treated with pediatric himtumor(HIT)-2000 protocol in Beijing Shijitan Hospital, Capital Medical University.All patients were performed tumor gross total resection, and someone accepted irradiation therapy firstly.The adverse effect of radiotherapy and chemotherapy was analyzed, and the 3-year progression-free survival (PFS) rate and overall survival (OS) rate were calculated by using Kaplan-Meier method.ResultsTill September 2017, the mean follow-up time was 3.0 years (0.2-4.8 years), and the survival rate was 72.2% (13/18 cases). Eleven cases(11/18 cases, 61.1%) were complete remission, but 7 cases (7/18 cases, 38.9%) relapsed during or after therapy.The 3-year PFS and OS rates were (66.7±11.1)% and (71.8±10.7)%, respectively.Moreover, 14 patients received craniospinal irradiation, and their 3-year PFS and OS rates were (68.8±13.3)% and (85.7±9.4)%, respectively, there was no significant difference between the overall rates(all P>0.05). During the follow-up period, all patients were not involved radiation-reduced brain necrosis, myelitis, and pancreatic injury.During the whole central radiotherapy, 14 children had different degree of blood routine abnormalities, mainly manifested in leukocytes and thrombocytopenia, and the blood routine was restored to normal after subcutaneous injection of granulocyte stimulating factor.The adverse reactions of the gastrointestinal tract were re-latively mild, mainly nausea and vomiting, and the improvement of the gastric mucosa and the protection of the gastric mucosa were all improved.The gastrointestinal tract adverse reactions caused by HIT-2000 were mainly nausea, vomiting, abdominal pain, diarrhea, constipation, and so on.The incidence of hematological adverse reactions was high, up to 100%, of which 2 cases were cured by active anti infection and symptomatic treatment due to the lack of granulocytic and fever.ConclusionHIT-2000 protocol is a feasible and efficient therapy method for sPNET of Chinese children patients, and the adverse effects are tolerable.Key words: Child; Primitive neuroectoderma; Central nervous system; Chemotherapy" @default.
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- W3031122912 date "2018-08-05" @default.
- W3031122912 modified "2023-09-23" @default.
- W3031122912 title "Clinical characteristic and survival analysis of childhood supratentorial primitive neuroectoderma: a center re-trospective study" @default.
- W3031122912 doi "https://doi.org/10.3760/cma.j.issn.2095-428x.2018.15.012" @default.
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