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- W3031127719 abstract "ObjectiveTo investigate the failure patterns and oligometastasis after concurrent chemoradiotherapy for stage III-IV non-small cell lung cancer (NSCLC), and to discuss the significance of local radiotherapy.MethodsThe patterns of failure including oligometastasis were analyzed in 299 previously untreated patients with stage III-IV NSCLC who underwent concurrent chemoradiotherapy from 2007 to 2014.ResultsOf all the patients with NSCLC, 88 patients with stage III NSCLC failed, among whom 22(22.7%) experienced primary tumor recurrence with or without distant metastasis and 27(30.7%) experienced oligometastasis, and brain metastasis was the most common failure pattern. A total of 211 patients with stage IV NSCLC failed, among whom 11.4% experienced primary tumor recurrence with or without distant metastasis, 10.0% experienced recurrence of the primary metastatic lesions, and 9.0% experienced new lesions in the organs with metastasis; 9 out of 94 patients with oligometastasis and 12 out of 117 patients without oligometastasis, respectively, experienced recurrence of the primary metastatic lesions. Brain metastasis had the highest incidence rate (38.2%).ConclusionsAfter concurrent chemoradiotherapy, nearly 1/3 patients with stage III NSCLC and 10% patients with stage Ⅳ NSCLC experience the failure of oligometastasis, and brain metastasis is the most common pattern of failure. Radical radiotherapy for primary tumors in stage IV NSCLC can reduce local recurrence.Key words: Cancer, non-small-cell/concurrent chemoradiotherapy; Oligometastases; Failure analysis" @default.
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- W3031127719 date "2016-01-15" @default.
- W3031127719 modified "2023-09-24" @default.
- W3031127719 title "Failure patterns and oligometastasis after concurrent chemoradiotherapy for stage III-IV non-small cell lung cancer" @default.
- W3031127719 doi "https://doi.org/10.3760/cma.j.issn.1004-4221.2016.01.006" @default.
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