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- W3031138809 abstract "ObjectiveTo evaluate the accuracy of serum pro-adrenomedullin(pro-ADM) concentration in predicting sepsis at different degrees of severity.MethodsA total of 145 patients of both sexes, aged 18-64 yr, who were admitted to intensive care unit (ICU) of the First Hospital of Hebei Medical University from March 2015 to April 2017, with length of ICU stay>24 h, were enrolled.The patients were divided into 3 groups according to the Sequential Organ Failure Assessment (SOFA) score within 24 h after admission to ICU: 2 12 severe sepsis group (n=45). Peripheral venous blood samples were collected immediately after admission to hospital for determination of serum pro-ADM concentrations by enzyme-linked immunosorbent assay.The receiver operating characteristic (ROC) curve of pro-ADM in predicting sepsis at different degrees of severity was plotted, and the area under the curve and 95% confidence interval, cut-off value, sensitivity and specificity were calculated.ResultsThe serum pro-ADM concentrations were significantly increased with the severity of sepsis, and the length of ICU stay was prolonged with the severity of sepsis (P<0.05). In mild sepsis group, the area under the ROC curve was 0.770, 95% confidence interval 0.591-0.949, sensitivity 0.725, specificity 0.700 and cut-off value 6.45 nmol/L.In moderate sepsis group, the area under the ROC curve was 0.776, 95% confidence interval 0.645-0.907, sensitivity 0.813, specificity 0.760, cut-off value 8.30 nmol/L.In severe sepsis group, the area under the ROC curve was 0.83, 95% confidence interval 0.715-0.963, sensitivity 0.73, specificity 0.800, cut-off value 5.70 nmol/L.ConclusionSerum pro-ADM concentration can be used as a reliable index in predicting sepsis at different degrees of severity.Key words: Adrenomedullin; Sepsis" @default.
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- W3031138809 date "2018-05-20" @default.
- W3031138809 modified "2023-09-28" @default.
- W3031138809 title "Accuracy of serum pro-adrenomedullin concentration in predicting sepsis at different degrees of severity" @default.
- W3031138809 doi "https://doi.org/10.3760/cma.j.issn.0254-1416.2018.05.023" @default.
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