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- W3031144186 abstract "ObjectiveTo evaluate clinical effect of volume modulated arc therapy(VMAT) for spinal metastases.MethodsTwenty patients with spinal metastases who had been treated with VMAT were chosen to participate in the study. The prescribed dose varied from 45 to 60 Gy within 15-20 fractions, 3 Gy per fraction, and one fraction per day of VMAT. Pain and quality of life were measured before VMAT and at several time points up to 6 months after treatment, by the numerical rating scale (NRS) and verbal rating scale (VRS) and the quality of life scale for bone metastases (EORTC QLQ-BM22) questionnaire. In addition, Frankel grading was used to evaluate the neurological function of spinal cord. The primary endpoint was frequency and duration of complete pain relief, and the secondary endpoint was death.ResultsAt the end of the follow-up, the number of patients reporting no pain from spinal metastases, as measured by the NRS, increased from 0 of 20 before VMAT to 10 of 14 (t=20.24, P 0.05). After VMAT, the patients who suffered from nerve function impairment recovered to different extent. No one had radiation-induced injury, such as radiation myelitis, radiation pneumonitis, etc. Median survival time was 10 month.ConclusionsVMAT is a safe and effective treatment method for spinal metastases. Significant reductions in patient-reported pain were observed, along with nerve dysfunction improved. The patients′ quality of life was significantly improved. VMAT has no late spinal cord toxicities.Key words: Volume modulated arc therapy; Spinal metastases; Pain; Quality of life" @default.
- W3031144186 created "2020-06-05" @default.
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- W3031144186 date "2017-01-25" @default.
- W3031144186 modified "2023-09-25" @default.
- W3031144186 title "Analysis on volume modulated arc therapy for spinal metastases" @default.
- W3031144186 doi "https://doi.org/10.3760/cma.j.issn.0254-5098.2017.01.007" @default.
- W3031144186 hasPublicationYear "2017" @default.
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