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- W3031148015 abstract "ObjectiveTo explore the effect of exercise on the expression of the LINGO-1 gene after intra-cerebral hemorrhage (ICH).MethodsSeventy-two Sprague-Dawley rats were randomly divided into a sham operation group, a control group and an exercise training group, each of 24. The three groups were further divided into 1 d, 3 d, 7 d and 14 d groups. ICH was induced using intra-parenchymal injection of autologous blood. The exercise training group was then forced to exercise on a treadmill. Any recovery of neurological functional was evaluated using Longa scoring, and the expression of LINGO-1 mRNA and protein were detected using the reverse transcription-polymerase chain reaction and western blotting.ResultsThe sham operation group displayed no obvious neurological deficiency, with little expression of LINGO-1 mRNA or protein at any time point. The control group′s average Longa score reached a maximum of 3 seven days after the operation, decreasing to 2 after another 7 days. The average expression of LINGO-1 mRNA and protein in that group peaked at 1.335±0.393 three days after the ICH, then decreased to 0.429±0.035 on the 7th day and 0.371±0.038 on the 14th day. In the exercise training group the average Longa score on the 7th day was 2, the average LINGO-1 mRNA level was 0.257±0.042 and the average protein level was 1.142±0.287, all significantly lower than in the control group. Moreover, in the exercise group there was a significant positive correlation between LINGO-1 protein expression and the Longa scores.ConclusionExercise can decrease the expression of LINGO-1 mRNA and protein and promote the recovery of neural function after ICH.Key words: LINGO-1 gene; Cerebral hemorrhage; Exercise; Nerve regeneration" @default.
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- W3031148015 date "2017-09-25" @default.
- W3031148015 modified "2023-09-23" @default.
- W3031148015 title "Effects of exercise on the expression of the LINGO-1 gene in rats after intra-cerebral hemorrhage" @default.
- W3031148015 doi "https://doi.org/10.3760/cma.j.issn.0254-1424.2017.09.001" @default.
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