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- W3031152081 abstract "目的 探讨ABCG5和ABCG8与结石形成的关系.方法测定结石组病人结石胆固醇含量,确定为胆固醇结石.比较禁食情况下胆固醇结石病人和胃癌病人中血脂、脂蛋白的差异,采用实时PCR方法比较胆固醇结石病人与胃癌病人ABCG5和ABCG8 mRNA的差异.结果两组病例血脂、脂蛋白比较无明显差异.胆固醇结石组ABCG5/beta-actin和ABCG8/beta-actin均高于胃癌组(为17.6%±9.8% vs 13.5%±6.2%,P<0.01;18.9%±7.1% vs 16.5%±4.2%,P<0.01),说明胆固醇结石病人在基础情况下ABCG5和ABCG8有较高的转录水平.结论本研究提示胆固醇结石的形成与肝脏ABCG5和ABCG8高表达,向胆汁中转运较多的胆固醇有关。" @default.
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- W3031152081 date "2005-09-28" @default.
- W3031152081 modified "2023-09-25" @default.
- W3031152081 title "Relation of ABCG5 and ABCG8 to formation of cholesterol gall stone" @default.
- W3031152081 doi "https://doi.org/10.3760/cma.j.issn.1007-8118.2005.09.003" @default.
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