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• W3031168049 abstract "ObjectiveTo investigate the safety and feasibility of a simplified protocol combining with mesenchymal stem cell (MSC) in ABO-incompatible (ABO-I) liver transplant patients.MethodsTwelve ABO-I liver transplant patient who received the therapy of a simplified protocol combining with MSC in the Third Affiliated Hospital of Sun Yat-sen University between January 2014 and September 2015 were recruited in this prospective study. Ten cases were male and 2 were female, with a mean age of (39±13) years old. The informed consents of all patients or their families were obtained and the local ethical committee approval was received. A immunologic tolerance induction protocol, plasma exchange + rituximab + intravenous immunoglobin + MSC (simplified protocol combining with MSC and without splenectomy and graft local infusion), was used to prevent the antibody-mediated rejection (AMR) after liver transplantation (LT). The perioperative condition and postoperative outcome of the patients were observed.ResultsThree death cases were observed after LT including 2 cases died of multiple organ failure and 1 of gastrointestinal hemorrhage. The other cases survived. Two cases developed acute cellular rejection and no AMR case was observed. Biliary complication was observed in 3 cases, hepatic artery stenosis in 1 case and infection in 6 cases.ConclusionThe simplified protocol combining with MSC is safe and effective in preventing the AMR after ABO-I LT.Key words: Mesenchymal stem cells; Liver transplantation; ABO blood-group system; Blood group incompatibility; Immunosuppression" @default.
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• W3031168049 date "2016-12-10" @default.
• W3031168049 modified "2023-09-26" @default.
• W3031168049 title "Application of simplified protocol combining with mesenchymal stem cell in ABO-incompatible liver transplant patients" @default.
• W3031168049 doi "https://doi.org/10.3877/cma.j.issn.2095-3232.2016.06.009" @default.
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