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- W3031168324 abstract "ObjectiveTo investigate the risk factors of atrial fibrillation (AF) in hyperthyroidism patients.MethodsThe clinical data of 557 patients with hyperthyroidism receiving 131I treatment from January 2015 to May 2018 were enrolled in the study. There were 50 cases with AF and 507 patients without AF before the treatment. Univariate and multivariate logistic regression were applied to analyze the risk factors of AF in hyperthyroidism patients.ResultsCompared to non-AF patients, AF patients had older age [(59.1±10.6) vs. (41.9±13.7) years, t=6.75, P<0.01], more males[42.0%(21/50] vs. 19.7%(100/507), χ2=14.11, P<0.01], longer duration of hyperthyroidism [66.0 (6.8, 120.0) vs. 12.0(3.0, 72.0) months, Z=2.83, P=0.02], higher prevalence of coronary artery disease [16.0%(8/50) vs. 2.6%(13/507)] and hypertension[30.0%(15/50) vs. 9.3%(47/507)], higher serum creatinine (SCr) [51.5(46.0, 64.3) vs. 42.0(35.0, 51.0) μmol/L, Z=4.62, P<0.01], serum uric acid (SUA) [(360.6±90.3) vs. (313.4±80.3) μmol/L, t=3.76, P<0.01]and gamma-glutamy transpeptidase (GGT)[72.1 (38.0, 97.0) vs. 42.2(17.0,48.8) U/L, Z=4.97, P<0.01] and total bilirubin (TBIL) (21.3±8.8) vs. (13.8±7.7) U/L, t=5.26, P<0.01], direct bilirubin(DBIL)[12.6(7.9,17.4) vs. 5.5(4.1,7.9)μmol/L, Z=6.62, P=0.00)]and lower blood platelet (PLT) [(188.5±60.8) ×109/L vs. (241.0±65.1)×109/L, t=4.52, P<0.01]. And there were no significant differences in thyroid hormone level and thyroid autoimmune antibody levels. Univariate and multivariate analysis showed that the age (OR=1.23, 95%CI: 1.09-1.38, P<0.01), SUA (OR=1.01, 95%CI: 1.00-1.20, P=0.05), DBIL (OR=1.65, 95%CI: 1.01-2.72, P=0.05), GGT (OR=1.04, 95%CI: 1.01-1.08, P=0.01) were risk factors for AF in patients with hyperthyroidism.ConclusionOlder age, abnormal serum SUA, DBIL and GGT are risk factors for atrial fibrillation in patients with hyperthyroidism, to timely control hyperthyroid and to give symptomatic treatment for those patients are necessary.Key words: Hyperthyroidism; Atrial fibrillation; Hyperuricemia; Bilirubin; Risk factors" @default.
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- W3031168324 date "2019-04-04" @default.
- W3031168324 modified "2023-09-23" @default.
- W3031168324 title "Risk factors of atrial fibrillation in hyperthyroidism patients" @default.
- W3031168324 doi "https://doi.org/10.3760/cma.j.issn.1671-7368.2019.04.012" @default.
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