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- W3031170876 abstract "Objective To explore the possible mechanism of the prevention effect of Tempol (TPL) on radiation-induced submandibular gland dysfunction using a C57bl/6 mouse model.Methods One-hundred twenty male C57bl/6 mice were randomly divided into six groups:blank control group,radiation group,25 mg/kg TPL group,200 mg/kg TPL group,25 mg/kg TPL + radiation group and 200 mg/kg TPL + radiation group.25 mg/kg and 200 mg/kg TPL was injected to mice enterocoelia 10 min before 15 Gy X-ray radiation.Survival rate and weight change of the mice were observed 30 d after radiation.Salivary flow rate and mandibular gland apoptosis were detected at 3 and 30 d after radiation.Total superoxide dismutase activity,total glutathione and malondialdehyde content and Bcl-2,Bax,Caspase 3 expression levels were detected at 3 d after radiation.Results Salivary flow rates at 3 and 30 days in the radiation group were 5.67 ± 1.05 and 5.27 ± 1.34,lower than that of 200 mg/kg TPL + radiation group (13.12 ±1.17,13.09 ±2.71) significantly (F=226.4,215.3,P＜0.05) but had no significant difference (P ＞ 0.05) compared with 25 mg/kg TPL + radiation group (6.44 ± 1.09,5.48 ± 1.79).Pretreatment of mice with 200 mg/kg TPL could reduce radiation induced apoptosis and the content of MDA in tissue but increased the GSH content.The TPL also increased the activity of SOD,the expression of Bcl-2 protein level,but reduced the levels of Bax and cleaved Caspase-3 protein.Conclusions 200 mg/kg TPL could protect C57bl/6 mice salivary glands from radiation injury probably by alleviating oxidative stress and regulating the mitochondrial pathway of apoptosis except 25 mg/kg TPL.Key words: Radiation injury; Tempol; Oxidative stress; Submandibular gland" @default.
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- W3031170876 date "2014-03-25" @default.
- W3031170876 modified "2023-09-24" @default.
- W3031170876 title "Mechanism of the prevention effect of a free radical scavenger, Tempol, on radiation-induced dysfunction in the submandibular gland of mouse" @default.
- W3031170876 doi "https://doi.org/10.3760/cma.j.issn.0254-5098.2014.03.005" @default.
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