Matches in SemOpenAlex for { <https://semopenalex.org/work/W3031174201> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W3031174201 endingPage "665" @default.
- W3031174201 startingPage "662" @default.
- W3031174201 abstract "ObjectiveTo study the mRNA expressions of various CD97 isoforms in colorectal carcinoma tissues and their clinical significances.MethodsA total of 50 colon cancer patients in the First Affiliated Hospital of Wenzhou Medical University from December 2013 to May 2014 and human colon cancer cell lines SW480 and SW620 were enrolled. The real-time fluorescence quantitative polymerase chain reaction (qRT-PCR) was used to detect the mRNA expressions of CD97 human epidermal growth factor (EGF) (1, 2, 5), CD97EGF (1, 2, 3, 5) and CD97EGF (1, 2, 3, 4, 5) in colon cancer tissues, adjacent tissues, normal colon tissues, SW480 cells and SW620 cells. The relationship between the mRNA expression of CD97EGF (1, 2, 5) and the clinicopathological factors was analyzed.ResultsCompared with those low expressions in adjacent tissues and normal tissues, the mRNA expressions of CD97 isoforms CD97EGF (1, 2, 5), CD97EGF (1, 2, 3, 5) and CD97EGF (1, 2, 3, 4, 5) in cancer tissues were highest, and the differences were statistically significant (0.71±0.20 vs. 0.40±0.09 vs. 0.35±0.07, F = 107.642, P < 0.01; 0.45±0.11 vs. 0.26±0.05 vs. 0.27±0.06, F = 94.231, P < 0.01; 0.41±0.10 vs. 0.21±0.05 vs. 0.19±0.03, F = 165.672, P < 0.01). In addition, the mRNA expression of CD97EGF (1, 2, 5) in colon cancer patients was associated with tumor infiltration depth (T1-T2 and T3-T4), clinical stages (Ⅰ-Ⅱ and Ⅲ-Ⅳ), and the differences were statistically significant (t = -2.582, P = 0.013; t = -5.062, P < 0.01). The mRNA expression of CD97EGF (1, 2, 5) in SW620 cells was higher than that in SW480 cells.ConclusionsCD97 isoforms are highly expressed in colon cancer tissues, and CD97EGF (1, 2, 5) may play an important role in the development and invasion of colon cancer. The CD97 isoforms may be new markers in the treatment of colon cancer.Key words: Colonic neoplasms; Isoform, CD97; Reverse transcriptase polymerase chain reaction; Pathology, clinical" @default.
- W3031174201 created "2020-06-05" @default.
- W3031174201 creator A5022164362 @default.
- W3031174201 creator A5043910952 @default.
- W3031174201 creator A5045025919 @default.
- W3031174201 creator A5057711372 @default.
- W3031174201 creator A5060622486 @default.
- W3031174201 creator A5078660282 @default.
- W3031174201 creator A5080410551 @default.
- W3031174201 date "2019-10-28" @default.
- W3031174201 modified "2023-09-27" @default.
- W3031174201 title "Expressions of CD97 isoforms in colon cancer tissues and their clinical significances" @default.
- W3031174201 doi "https://doi.org/10.3760/cma.j.issn.1006-9801.2019.10.004" @default.
- W3031174201 hasPublicationYear "2019" @default.
- W3031174201 type Work @default.
- W3031174201 sameAs 3031174201 @default.
- W3031174201 citedByCount "0" @default.
- W3031174201 crossrefType "journal-article" @default.
- W3031174201 hasAuthorship W3031174201A5022164362 @default.
- W3031174201 hasAuthorship W3031174201A5043910952 @default.
- W3031174201 hasAuthorship W3031174201A5045025919 @default.
- W3031174201 hasAuthorship W3031174201A5057711372 @default.
- W3031174201 hasAuthorship W3031174201A5060622486 @default.
- W3031174201 hasAuthorship W3031174201A5078660282 @default.
- W3031174201 hasAuthorship W3031174201A5080410551 @default.
- W3031174201 hasConcept C104317684 @default.
- W3031174201 hasConcept C105580179 @default.
- W3031174201 hasConcept C121332964 @default.
- W3031174201 hasConcept C121608353 @default.
- W3031174201 hasConcept C126322002 @default.
- W3031174201 hasConcept C142724271 @default.
- W3031174201 hasConcept C143998085 @default.
- W3031174201 hasConcept C153400128 @default.
- W3031174201 hasConcept C170493617 @default.
- W3031174201 hasConcept C2776362946 @default.
- W3031174201 hasConcept C2777546739 @default.
- W3031174201 hasConcept C2991914351 @default.
- W3031174201 hasConcept C48023723 @default.
- W3031174201 hasConcept C526805850 @default.
- W3031174201 hasConcept C53345823 @default.
- W3031174201 hasConcept C55493867 @default.
- W3031174201 hasConcept C63363279 @default.
- W3031174201 hasConcept C71924100 @default.
- W3031174201 hasConcept C86803240 @default.
- W3031174201 hasConcept C90924648 @default.
- W3031174201 hasConcept C97355855 @default.
- W3031174201 hasConceptScore W3031174201C104317684 @default.
- W3031174201 hasConceptScore W3031174201C105580179 @default.
- W3031174201 hasConceptScore W3031174201C121332964 @default.
- W3031174201 hasConceptScore W3031174201C121608353 @default.
- W3031174201 hasConceptScore W3031174201C126322002 @default.
- W3031174201 hasConceptScore W3031174201C142724271 @default.
- W3031174201 hasConceptScore W3031174201C143998085 @default.
- W3031174201 hasConceptScore W3031174201C153400128 @default.
- W3031174201 hasConceptScore W3031174201C170493617 @default.
- W3031174201 hasConceptScore W3031174201C2776362946 @default.
- W3031174201 hasConceptScore W3031174201C2777546739 @default.
- W3031174201 hasConceptScore W3031174201C2991914351 @default.
- W3031174201 hasConceptScore W3031174201C48023723 @default.
- W3031174201 hasConceptScore W3031174201C526805850 @default.
- W3031174201 hasConceptScore W3031174201C53345823 @default.
- W3031174201 hasConceptScore W3031174201C55493867 @default.
- W3031174201 hasConceptScore W3031174201C63363279 @default.
- W3031174201 hasConceptScore W3031174201C71924100 @default.
- W3031174201 hasConceptScore W3031174201C86803240 @default.
- W3031174201 hasConceptScore W3031174201C90924648 @default.
- W3031174201 hasConceptScore W3031174201C97355855 @default.
- W3031174201 hasIssue "10" @default.
- W3031174201 hasLocation W30311742011 @default.
- W3031174201 hasOpenAccess W3031174201 @default.
- W3031174201 hasPrimaryLocation W30311742011 @default.
- W3031174201 hasRelatedWork W2340827652 @default.
- W3031174201 hasRelatedWork W2344906553 @default.
- W3031174201 hasRelatedWork W2349619094 @default.
- W3031174201 hasRelatedWork W2350308329 @default.
- W3031174201 hasRelatedWork W2353656001 @default.
- W3031174201 hasRelatedWork W2369519561 @default.
- W3031174201 hasRelatedWork W2389493775 @default.
- W3031174201 hasRelatedWork W2391131475 @default.
- W3031174201 hasRelatedWork W2435974018 @default.
- W3031174201 hasRelatedWork W2473450043 @default.
- W3031174201 hasRelatedWork W2474725235 @default.
- W3031174201 hasRelatedWork W2763672654 @default.
- W3031174201 hasRelatedWork W2989966571 @default.
- W3031174201 hasRelatedWork W3000643389 @default.
- W3031174201 hasRelatedWork W3029965266 @default.
- W3031174201 hasRelatedWork W3030575088 @default.
- W3031174201 hasRelatedWork W3031778772 @default.
- W3031174201 hasRelatedWork W3032027521 @default.
- W3031174201 hasRelatedWork W3143381709 @default.
- W3031174201 hasRelatedWork W3144821962 @default.
- W3031174201 hasVolume "31" @default.
- W3031174201 isParatext "false" @default.
- W3031174201 isRetracted "false" @default.
- W3031174201 magId "3031174201" @default.
- W3031174201 workType "article" @default.