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- W3031188537 abstract "Toll样受体(Toll Like Receptors,TLRs)在天然免疫中发挥着重要的作用.近年,越来越多的证据表明TLRs也参与了天然免疫系统对病毒的识别,同时它在病毒感染及其转归中也扮演了重要的角色.TLR3、TLR4、TLR7、TLR8、TLR9等TLRs可识别特异性蛋白、DNA和RNA等病毒源性分子,启动胞内抗病毒信号传导机制,通过一系列转接蛋白和转录因子,介导了以干扰素反应为主要机制的固有免疫防御机制,同时也参与调控针对病毒的特异性免疫应答.此外,某些病毒具有针对TLRs的免疫逃逸机制。" @default.
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- W3031188537 date "2007-09-05" @default.
- W3031188537 modified "2023-09-25" @default.
- W3031188537 title "The anti-virus effect triggered by Toll-like receptors and its mechanism" @default.
- W3031188537 doi "https://doi.org/10.3760/cma.j.issn.1673-4394.2007.05.018" @default.
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