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- W3031192214 abstract "ObjectiveTo study the correlation of the adiponectin receptor 1 gene rs1139646C/G and rs10920531C/A single nucleotide polymorphisms with Chinese Han women with polycystic ovary syndrome (PCOS).MethodsFor PCOS group (n=80) and control group (n=80), polymerase chain reaction (PCR) was used to amplify the upstream and downstream 250 bases of rs1139646C/G and rs10920531C/A, respectively. PCR products were directly sequenced.ResultsFor rs1139646C/G loci sites between PCOS and control groups, all were the homozygous genotype CC, and no statistical significance was found for genotype frequency and allele frequency between two groups. For rs10920531C/A loci sites between PCOS and control groups, no statistical significance was found for genotype frequency and allele frequency between two groups (P=0.683, 0.580), and no statistical significance was found for two loci with genetic linkage disequilibrium analysis (χ2=0.307, Fisher 's P=0.579610, Pearson' s P=0.579608).ConclusionsAdiponectin receptor 1 gene rs1139646C/G and rs10920531C/A single nucleotide polymorphisms have nothing to do with Chinese Han PCOS women. Genetic linkage disequilibrium analysis has nothing to do with PCOS. The rs1139646C/G in Chinese Han population is relatively stable site, and no locus mutation is found.Key words: Receptors, adiponectin/GE; Polycystic ovary syndrome/GE" @default.
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- W3031192214 date "2015-08-20" @default.
- W3031192214 modified "2023-09-24" @default.
- W3031192214 title "Preliminary study of adiponectin receptor 1 gene polymorphisms and polycystic ovary syndrome" @default.
- W3031192214 doi "https://doi.org/10.3760/cma.j.issn.1008-1372.2015.08.017" @default.
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